Aerosolized Antibiotics | Respiratory Care
网页2015年6月1日 · Aerosolized antibiotics have been tested as treatment for bacterial infections in patients with cystic fibrosis (CF), non-CF bronchiectasis (NCFB), and ventilator-associated pneumonia (VAP). The most successful application of this to date is treatment of infections in patients with CF.
Aerosolized antibiotics in the treatment of hospital-acquired …
网页2021年10月21日 · Aerosolized antibiotics are being increasingly used to treat respiratory infections, especially those caused by drug-resistant pathogens. Their use in the treatment of hospital-acquired pneumonia and ventilator-associated pneumonia in critically ill patients is especially significant. They are also used as an efficient alternative to overcome ...
Inhaled Antibiotics for Lower Airway Infections - PMC
网页2013年11月13日 · Inhaled antibiotics have been used to treat chronic airway infections since the 1940s. The earliest experience with inhaled antibiotics involved aerosolizing antibiotics designed for parenteral administration. These formulations caused significant bronchial irritation due to added preservatives and nonphysiologic chemical composition.
Use of nebulized antimicrobials for the treatment of respiratory ...
网页One RCT evaluating the use of nebulized antibiotics (aminoglycosides and ceftazidime, without other concomitant IV antibiotics) to treat VAP caused by antibiotic-susceptible pathogens, in comparison to the use of those IV antibiotics, was considered to have an administration strategy equivalent to the substitution strategy, and therefore ...
Aerosolized antibiotics: do they add to the treatment of …
网页2013年11月6日 · Preliminary clinical studies reveal that aerosolized delivery of antibiotics is well tolerated and active, when combined with intravenous antibiotics. No single aerosolized antibiotic is likely to provide broad-spectrum activity against both Gram-negative and Gram-positive bacteria.
Aerosolized Antibiotics for Treatment of Pneumonia in …
网页2019年8月1日 · There are several clinical settings in which aerosolized antibiotics could be used for treating pneumonia, including their use for prevention, as monotherapy, as adjunctive therapy with systemic antibiotics, and for treatment of extensively drug-resistant or pan drug-resistant pathogens.
Consensus Summary of Aerosolized Antimicrobial Agents: Application of ...
网页2012年1月6日 · With the paucity of consensus regarding the safety, efficacy, and means with which to use aerosolized antimicrobials, a task force was created by the Society of Infectious Diseases Pharmacists to critically review and evaluate the literature on the use of aerosolized antiinfective agents.
Aerosolised antibiotics in critical care - Intensive Care Medicine
网页2023年4月21日 · Delivery of inhaled antibiotics to treat ventilator-associated tracheobronchitis (VAT) or cystic fibrosis bronchiectasis follows a slightly different rationale. As aerosolised polymyxins and aminoglycosides are concentration-dependent antibiotics, the bactericidal effect is proportional to the delivered dose.
Full article: Aerosolized antibiotics: the past, present and future ...
网页2012年4月19日 · Inhaled antibiotics, such as TOBI (a tobramycin solution), gentamicin, colistin and aztreonam lysine (Cayston) have been effectively administered with safety and efficacy in patients with cystic fibrosis and bronchiectasis.
Inhaled antibiotics in critical care: State of the art and future ...
网页2022年9月1日 · In critically ill patients, some studies suggest a benefit of aerosolized antibiotic, which is primarily considered for the treatment of ventilator-associated pneumonia involving extensively drug-resistant bacteria and classically prescribed jointly with an intravenous antibiotic as a therapy of last resort, on a case-by-case basis.