Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge …
网页2023年6月28日 — Through GWAS analysis, whole-genome sequencing, and other analytical methods, genes associated with alopecia areata (AA) have been identified, mainly focusing on immune regulation genes, HLA genes, and inflammation-related pathway genes. Immune regulation genes such as FASLG, PTPN22, and NOTCH4 are involved in T cell regulation and differentiation.
Genetic Basis of Alopecia Areata: A Roadmap for Translational …
网页Alopecia Areata (AA) is a recurrent autoimmune type of hair loss that affects about 5.3 million people in the United States alone. Despite being the most prevalent autoimmune disease, affecting more individuals than most other autoimmune diseases combined, the molecular and cellular mechanisms underlying this complex disease are still poorly ...
Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge
网页2023年6月28日 — Through GWAS analysis, whole-genome sequencing, and other analytical methods, genes associated with alopecia areata (AA) have been identified, mainly focusing on immune regulation genes, HLA genes, and inflammation-related pathway genes. Immune regulation genes such as FASLG, PTPN22, and NOTCH4 are involved in T cell regulation and differentiation.
Clinical and Genetic Aspects of Alopecia Areata: A Cutting
网页2023年6月28日 — Alopecia areata (AA) is a chronic, non-scarring, immune-mediated skin disease that affects approximately 0.5-2% of the global population. The etiology of AA is complex and involves genetic and environmental factors, with significant advancements in genetic research occurring in recent years.
Integrated single-cell chromatin and transcriptomic analyses of …
网页We identified only 31 alopecia areata fmGWAS-linked genes, but these included examples involved in T cell functions such as IL21, ICOS and IRF4 (Extended Data Fig. 9b).
Whole exome sequencing in Alopecia Areata identifies rare
网页2022年2月10日 — In this work, we utilize whole exome sequencing to successfully identify a significant Alopecia Areata disease-relevant gene, KRT82, and reveal a proposed mechanism for rare variant...
Recent advances in the genetics of alopecia areata - PMC
网页2023年4月5日 — In general, genome-wide gene expression studies in AA generated converging and consistent evidence for 1) upregulation of interferon gamma (IFN-γ) response genes, (e. g. CXCL9, CXCL10, and CXCL11, encoding for inflammatory chemokines) and 2) downregulation of hair keratin (KRT) and keratin associated protein (KRTAP) genes in AA. IFN-γ is a ...
Alopecia Areata: A Review of the Genetic Variants and ... - PubMed
网页Alopecia areata (AA) is an autoimmune form of non-scarring hair loss that occurs on a spectrum from patchy loss of hair on the scalp, to complete hair loss. ... A better …
The genetics of alopecia areata: New approaches, new findings, …
网页Schematic representation of the susceptibility genes for alopecia areata discovered so far. 5.1. Genes related to the immune system5.1.1. Human leukocyte antigen (HLA)-related …
Thyroid Dysfunction and Alopecia Areata: A Genetic Prediction …
网页4 天之前 — 1 Introduction. Alopecia areata (AA) is a common autoimmune skin disease, with a lifetime prevalence of about 2% worldwide [].It can occur at any age, but most cases are found in young people under 20 years old, with approximately 25%−50% of patients being younger than 20 years before the first onset [].The clinical presentation of AA primarily includes one or several round or oval bald ...