BINDING OF THE RESPIRATORY CHAIN INHIBITOR ANTIMYCIN TO …
网页2005年8月8日 · Antimycin A (antimycin), one of the first known and most potent inhibitors of the mitochondrial respiratory chain, binds to the quinone reduction site of the cytochrome bc1 complex.
Mitochondrial Electron Transport Chain Complex III Is Required for ...
网页2011年11月11日 · Here we report that mitochondrial electron transport chain (mETC) complex III plays a role in autophagy induction. We show that antimycin A, a known inhibitor of mETC complex III, can inhibit autophagy.
Antimycin A-Induced Mitochondrial Damage Causes Human RPE …
网页2019年3月17日 · Here, we induced mitochondrial damage in human RPE cells (ARPE-19 and hRPE), using antimycin A, an inhibitor of complex III of the electron transport chain, and investigated cellular viability, mitochondrial structure and …
Binding of the respiratory chain inhibitor antimycin to the ...
网页2005年8月19日 · Antimycin A (antimycin), one of the first known and most potent inhibitors of the mitochondrial respiratory chain, binds to the quinone reduction site of the cytochrome bc1 complex. Structure-activity relationship studies have shown that the N-formylamino-salicyl-amide group is responsible for most of the binding specificity, and suggested that ...
Mitochondrial electron transport chain is necessary for NLRP3
网页2022年4月28日 · Antimycin releases superoxide from mitochondrial complex III both in the mitochondrial matrix and intermembrane space 44. By contrast, myxothiazol inhibits mitochondrial superoxide production at...
Comparison of the effect of mitochondrial inhibitors on …
网页2003年3月19日 · Inhibition of respiration by antimycin A or uncoupling of mitochondria by FCCP decreased ΔΨ m in both cell lines. Inhibition of ATP production by oligomycin or atractyloside induced a moderate decrease of ΔΨ m in HeLa G cells and an increase of ΔΨ m in BSC-40 cells.
The therapeutic potential of mitochondrial toxins | The Journal …
网页2021年6月23日 · Mitochondrial toxins that act as inhibitors of respiratory chain complexes in oxidative phosphorylation (OXPHOS) are typically avoided during drug discovery efforts, as such compounds can...
Antimycin A-induced cell death depends on AIF translocation
网页2009年2月20日 · Antimycin A (AA) inhibits mitochondrial electron transport at complex III, 1 thereby inhibiting respiration. The blockade of electron transport causes a collapse of the proton gradient across...
Antimycin A - Wikipedia
网页Antimycin A is an inhibitor of cellular respiration, specifically oxidative phosphorylation. Antimycin A binds to the Qi site of cytochrome c reductase, inhibiting the reduction of ubiquinone to ubiquinol in the Qi site, thereby disrupting the Q-cycle of enzyme turn over. It also will cause the disruption of the entire electron transport chain.
网页Results: Inhibition of respiration by antimycin A or un-coupling of mitochondria by FCCP decreased in. m. both cell lines. Inhibition of ATP production by oligomy-cin or atractyloside induced a moderate decrease of. m. in HeLa G cells and an increase of m in BSC-40 cells.