Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER ...
网页Asters are ER-resident proteins that mediate nonvesicular sterol transport. •. The sterol-binding ASTER domain is structurally related to the START domain. •. Asters are dynamically recruited to PM-ER contacts in response to cholesterol. •.
Aster-dependent nonvesicular transport facilitates dietary
网页Aster proteins (Aster-A, -B, and -C, encoded by Gramd1a, Gramd1b, and Gramd1c, respectively) bind cholesterol and facilitate its movement between membranes (25–27). Members of this family have a central cholesterol-binding pocket that is flanked by a GRAM domain at the N terminus and an ER transmembrane domain at the C terminus.
Aster Proteins Regulate the Accessible Cholesterol Pool in the …
网页2020年9月14日 · Our data demonstrate that Aster proteins regulate the PM accessible cholesterol pool by moving surplus cholesterol to the ER. When Aster protein expression is reduced, the PM accessible pool is expanded and the ER pool contracts, as evident from increased activity of SREBP-regulated genes.
New insights into dietary cholesterol absorption - Nature
网页2023年12月1日 · Aster proteins are involved in the non-vesicular transport of cholesterol to the endoplasmic reticulum (ER) in enterocytes. Pharmacological inhibition of the Aster pathway reduced dietary...
Aster: A New Star in Cholesterol Trafficking - Cell Press
网页2018年10月4日 · Modeling reveals that the central ASTER (Greek for “star”) domain of the resulting proteins (named Aster-A, -B, and -C) display remarkable similarity to the sterol-binding START domain. Indeed, binding assays demonstrate that the ASTER domain has an affinity for cholesterol rivaling that of the canonical START-domain protein StARD1.
Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER ...
网页2018年10月4日 · Here, we describe three ER-resident proteins (Aster-A, -B, -C) that bind cholesterol and facilitate its removal from the plasma membrane. The crystal structure of the central domain of Aster-A broadly resembles the sterol-binding fold of mammalian StARD proteins, but sequence differences in the Aster pocket result in a distinct mode of ligand ...
Asters: rising stars in the cholesterol universe - Nature
网页2023年1月16日 · Each of the three Aster proteins (A, B and C) also contains an ER transmembrane domain and a cytosolic GRAM domain 4, which binds anionic phospholipids via a patch of basic residues 5. When the...
Selective Aster inhibitors distinguish vesicular and nonvesicular ...
网页2021年1月1日 · The Aster proteins are transporters that move cholesterol between the plasma membrane and the ER. Here, we develop and characterize small molecules that selectively inhibit one or more Aster proteins.
Hepatic nonvesicular cholesterol transport is critical for systemic ...
网页2023年1月16日 · The Aster family of proteins (Aster-A, Aster-B and Aster-C; encoded by Gramd1a, Gramd1b and Gramd1c) mediate nonvesicular transport of cholesterol from the PM to the ER 6. Asters are...
Aster依赖性非囊泡型转运促进膳食胆固醇摄取 - 科学网
网页2023年11月10日 · Aster缺乏的小鼠胆固醇吸收受损，可以预防饮食诱导的高胆固醇血症。 最后，Aster通路可以用小分子抑制剂靶向，以控制胆固醇的摄取。 总之，这些发现将Aster通路确定为膳食脂质吸收中一个生理上重要，且药理学上易于处理的节点。 附：英文原文. Title: Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake.