BanLec - Wikipedia
网页BanLec (also BanLec-I or Banana lectin) is a lectin from the jacalin-related lectin family isolated from the fruit of the bananas Musa acuminata and Musa balbisiana. BanLec is one of the predominant proteins in the pulp of ripe bananas and has binding specificity for mannose and mannose-containing oligosaccharides.
H84T BanLec has broad spectrum antiviral activity against human ...
网页2022年1月31日 · H84T BanLec is a molecularly engineered lectin cloned from bananas with broad-spectrum antiviral activity against several RNA viruses. H84T BanLec dimers bind glycoproteins containing...
Cell子刊：来自于香蕉凝集素的H84T-BanLec有潜力抵抗包括新冠 …
网页2022年10月31日 · 2020年1月13日，美国密歇根大学的密歇根大学医学院传染病系内科教授David Markovitz博士及其团队发现香蕉凝集素（banana lectin, BanLec）具有抗病毒作用，但是直接将它注射到体内，也会产生较大的副作用，比如炎症和危险的 免疫 反应。为此，他们对BanLec进行改造，把第84位的氨基酸从组氨酸（H）替换成了苏氨酸（T），所产生的BanLec衍生物（称为H84T-BanLec）在小鼠体内可安全地抵抗多种病毒，包括耐药 …
A broad-spectrum virus- and host-targeting peptide against
网页2020年8月25日 · Other groups have reported the broad-spectrum antiviral peptide BanLec which inhibits HIV, hepatitis C virus (HCV) and influenza virus 17, the theta-defensin retrocylin 2, which inhibits...
A molecularly engineered, broad-spectrum anti-coronavirus lectin ...
网页2022年10月18日 · Here, we show that the rationally engineered H84T-banana lectin (H84T-BanLec), which specifically recognizes high mannose found on viral proteins but seldom on healthy human cells, potently inhibits Middle East respir …
Characterization of a Molecularly Engineered Banlec-Type
网页The Banana Lectin (BanLec) is a member of the Jacalin-related Lectins, heavily studied for its immunomodulatory, antiproliferative, and antiviral activity. In this study, a novel sequence was generated in silico considering the native BanLec amino acid sequence and 9 other lectins belonging to JRL.
Pan-coronavirus antiviral activity and mechanism of molecularly ...
网页2022年10月26日 · BanLec is a lectin from the jacalin-related lectin family isolated from bananas. The molecularly engineered H84T-BanLec possesses preserved antiviral activity and reduced mitogenicity....
A molecularly engineered, broad-spectrum anti-coronavirus lectin ...
网页2022年10月10日 · Here, we show that the rationally engineered H84T-banana lectin (H84T-BanLec), which specifically recognizes high mannose found on viral proteins but seldom on healthy human cells, potently inhibits Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus 2 …
CAR-NK Cells Targeting Sars-Cov-2 Glycosites As COVID-19 …
网页2021年11月5日 · BanLec binds high mannose glycans expressed on the viral envelopes of HIV, Ebola, influenza, and coronaviruses. BanLec mitogenicity can be divorced from antiviral activity via a single amino acid change (H84T). The SARS-CoV-2 spike (S) protein is decorated with high mannose N-glycosites that are in …
BanLec-eGFP Chimera as a Tool for Evaluation of Lectin Binding to …
网页2021年1月28日 · BanLec is an IgG4-inducing antigen and a potent inhibitor of human immunodeficiency virus (HIV) replication [9,10]. BanLec binds to the glycosylated proteins in the viral envelope and inhibits its cellular entry by blocking glycan-mediated interactions with the CD4 receptor and CCR5/CCR4 co-receptors on host cells .