Beta-lactamase - Wikipedia
网页Beta-lactamases (β-lactamases) are enzymes (EC 3.5.2.6) produced by bacteria that provide multi-resistance to beta-lactam antibiotics such as penicillins, cephalosporins, cephamycins, monobactams and carbapenems , although carbapenems are relatively resistant to beta-lactamase.
β-Lactamases: Sequence, Structure, Function, and Inhibition
网页2021年7月5日 · β-Lactams were the first class of antibiotics to be discovered and the second to be introduced into the clinic in the 1940s [1]. They inhibit bacterial transpeptidases (also known as penicillin-binding proteins or PBPs) involved in peptidoglycan synthesis, thus inhibiting growth, and leading to lysis of bacteria.
Overview of Beta-Lactams - Overview of Beta-Lactams - The …
网页Beta-lactamases are a diverse class of enzymes produced by bacteria that break open the beta-lactam ring, inactivating the beta-lactam antibiotic. Some beta-lactamases are encoded on mobile genetic elements (eg, plasmids); others are encoded on chromosomes. Beta-lactamase production is among the most clinically important mechanisms of ...
β-Lactamases and β-Lactamase Inhibitors in the 21st Century
网页2019年8月8日 · An overview is provided of the changing landscape of β-lactamase inhibitors, exemplified by the introduction to the clinic of combinations of β-lactams with diazabicyclooctanone and cyclic boronate serine β-lactamase inhibitors, and of progress and strategies toward clinically useful MBL inhibitors.
β-内酰胺酶 - 维基百科，自由的百科全书
网页β-内酰胺酶 （β-lactamases），又稱為 盤尼西林酶 （Penicillinase）、 頭孢菌素酶 （Cephalosporinase），是一類由某些细菌生成来提供多重抗藥性， 对抗 β-内酰胺类抗生素 （比如 青霉素 、 头孢菌素 、 单酰胺环类 、 碳青霉烯 等）的 酶 (EC 3.5.2.6)。. β-内酰胺类 …
Beta-Lactamase - an overview | ScienceDirect Topics
网页Beta-lactamases are genetically and structurally closely related to penicillin-binding proteins. Despite their chemical diversity, their adverse effects profiles share various common aspects. There are several reasons why beta-lactam antibiotics belonging to different classes can cause comparable reactions.
β-Lactams and β-Lactamase Inhibitors: An Overview
网页β-Lactam antibiotics are bactericidal agents that interrupt bacterial cell-wall formation as a result of covalent binding to essential penicillin-binding proteins (PBPs), enzymes that are involved in the terminal steps of peptidoglycan cross-linking in both Gram-negative and Gram-positive bacteria.
β-Lactamases: Sequence, Structure, Function, and Inhibition
网页2021年7月5日 · β-Lactams were the first class of antibiotics to be discovered and the second to be introduced into the clinic in the 1940s [...].
Beta-Lactamase - an overview | ScienceDirect Topics
网页Beta-lactamase (EC 3.5.2.6) synthesis, particularly in Gram-negative bacilli, is a major mechanism of natural and acquired resistance to beta-lactams, sometimes accompanied by impermeability and/or active efflux. These enzymes have been classified into …
Beta-Lactamases and Their Classification: An Overview
网页2022年4月21日 · At present, beta-lactams consist of four primary groups based on their chemical structure: The penicillins, the cephalosporins, the carbapenems, and the monobactam. Penicillins have four-membered beta-lactam rings fused to a thiazolidine ring. In cephalosporins, the thiazolidine ring is substituted by dihydrothiazine.
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