Bile acid metabolism and signaling in health and disease ... - Nature
网页2024年4月26日 · Bile acid metabolism and signaling pathways play a crucial role in protecting against, or if aberrant, inducing cardiometabolic, inflammatory, and neoplastic conditions,...
The changing metabolic landscape of bile acids - Nature
网页2024年4月4日 · Bile acids regulate nutrient absorption and mitochondrial function, they establish and maintain gut microbial community composition and mediate inflammation, and they serve as signalling...
Role of bile acids and their receptors in gastrointestinal and …
网页2022年2月14日 · Bile acids (BAs) are synthesized from cholesterol in the hepatocytes (primary BAs) and, once secreted in the intestinal lumen, they are modified by the gut microbiota (secondary BAs) 1 (Fig. 1);...
Bile Acids and Biliary Fibrosis - PubMed
网页2023年3月2日 · Biliary fibrosis is the driving pathological process in cholangiopathies such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Cholangiopathies are also associated with cholestasis, which is the retention of biliary components, including bile acids, in the liver and blood. …
Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases
网页2023年7月19日 · Bile acids interact with bile acid receptors (BARs) or gut microbiota, which plays a key role in maintaining the homeostasis of the intestinal barrier. In this review, we summarize and discuss the recent studies on bile acid disorder associated with intestinal barrier dysfunction and related diseases.
Physiology, Bile Acids - StatPearls - NCBI Bookshelf
网页2023年5月1日 · Introduction. Bile acids are steroidal acids found in bile. Primary bile acids are steroids produced via the liver, specifically in peroxisomes. [1] [2] [3] There, the acids conjugate/connect to hydrophilic amino acids, namely glycine/taurine (i.e., conjugated bile acids called glycocholic and taurocholic acids, respectively); alongside sodium ...
Bile acids: Chemistry, physiology, and pathophysiology - PMC
网页2009年2月2日 · The family of bile acids includes a group of molecular species of acidic steroids with very peculiar physical-chemical and biological characteristics. They are synthesized by the liver from cholesterol through several complementary pathways that are controlled by mechanisms involving fine-tuning by the levels of certain bile acid species.
Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction
网页2021年7月28日 · The present review examines the question of the extent to which the increase in bile acids in plasma could be responsible for the hyperdynamic circulatory disturbance of liver cirrhosis and whether modulation of the bile acid pool, for example, via administration of ursodeoxycholic acid (UDCA) or via …
Effects of Therapeutically Approved Individual Bile Acids on The ...
网页2 天之前 · Bile acid (BA) signaling dysregulation is an important etiology for the development of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD). As diverse signaling molecules synthesized in the liver by pathways initiated with CYP7A1 and CYP27A1, BAs are endogenous modulators of farnesoid x receptor (FXR). ...
Bile Acids: A Bridge Linking Gut Microbiota and NAFLD
网页2022年11月16日 · Bile acids (BAs), the molecules that are first synthesized in hepatocytes and further metabolized by gut microbes, can either circulate in enterohepatic system or be found in circulations to exert various effects. Dysbiosis brings about the dysregulated BA composition, which is also observed in the pathology of NAFLD.
- 某些结果已被删除
跳至内容