Targeting mitochondrial bioenergetics as a promising therapeutic ...
网页2022年10月1日 — A large body of literature concludes that mitochondrial energetics and metabolism are disrupted in HD, and it is supported by many studies in mutant htt transgenic mice, cell culture models and HD patients. The activity of ETC complexes II, III and IV is reduced in HD brains [73].
Bioenergetics Communications
网页Bioenergetics Communications (BEC), the open-access journal for bioenergetics, mitochondrial and chloroplast physiology. Rapid dissemination in MitoFit Preprints, followed by Open Peer Review for publishing and sharing high-quality data. BEC Living Communications allow additions and corrections of a publication which evolves with …
ATAD3A oligomerization causes neurodegeneration by coupling ...
网页2019年3月26日 — Mitochondrial fragmentation and bioenergetic failure manifest in Huntington’s disease (HD), a fatal neurodegenerative disease. The factors that couple mitochondrial fusion/fission...
Mitochondrial bioenergetics and dynamics in Huntington’s …
网页2010年5月8日 — Preferential striatal neurodegeneration is a hallmark of Huntington’s disease (HD) pathogenesis, which has been associated with mitochondrial dysfunction. Evidence from genetic HD models suggest that mutant huntingtin (mHtt) compromises mitochondrial bioenergetics and dynamics, preventing efficient calcium handling and ATP generation in ...
On the cutting edge: perspectives in bioenergetics - Nature
网页2023年3月3日 — Bioenergetic mechanisms exist in harmony to maintain homeostasis within the cell; a careful investigation of these mechanisms is therefore necessary to understand their contributions to...
Biochimica et Biophysica Acta (BBA) - Bioenergetics | Journal ...
网页BBA Bioenergetics covers the area of biological membranes involved in energy transfer and conversion. In particular, it focuses on the structures obtained by X-ray crystallography and other approaches, and molecular mechanisms of the components of photosynthesis, mitochondrial and bacterial respira…. View full aims & scope.
Bioenergetics - an overview | ScienceDirect Topics
网页A possible underlying factor connecting coherence and progressive disorganization of molecular and genetic networks in cancer is cellular bioenergetics. The flow of energy through the cell is primarily mediated by the mitochondrion.
Bioenergetics - Nature
网页2023年8月16日 — Nuclear genetic control of mtDNA copy number and heteroplasmy in humans. We quantify mitochondrial DNA copy number and heteroplasmy levels and study their association with nuclear genetic loci in...
Bioenergetics - 4th Edition - Elsevier Shop
网页Covers new advances in the structure and mechanism of key bioenergetic proteins, including complex I of the respiratory chain and transport proteins; Details cellular bioenergetics, mitochondrial cell biology and signal transduction, and the roles of mitochondria in physiology, disease and aging
Bioenergetic medicine - PMC - National Center for Biotechnology …
网页2014年3月28日 — Bioenergetic medicine refers to the manipulation of bioenergetic fluxes to positively affect health. Bioenergetic medicine approaches rely heavily on the law of mass action, and impact systems that monitor and respond to the manipulated flux.