CA125 and Ovarian Cancer: A Comprehensive Review - PMC
网页2020年12月11日 · Among these biomarkers, Cancer Antigen 125 (CA125), also referred to as Carbohydrate Antigen 125, has played the most significant role in screening, detecting, and managing ovarian cancer for the last four decades. CA125 is a high molecular weight mucinous glycoprotein found on the surface of ovarian cancer cells.
Mucin-16 - Wikipedia
网页Mucin-16 (MUC-16) also known as Ovarian cancer-related tumor marker CA125 is a protein that in humans is encoded by the MUC16 gene. [3][4][5] MUC-16 is a member of the mucin family glycoproteins. [6]
Cancer Antigen 125 - StatPearls - NCBI Bookshelf
网页2024年5月2日 · Cancer antigen 125 (CA125) is an antigenic tumor marker expressed by epithelial ovarian neoplasms and cells lining various organs such as the endometrium, fallopian tubes, pleura, peritoneum, and pericardium.
CA125 in Ovarian Cancer - PMC - National Center for …
网页Twenty five years after its discovery, circulating CA125 antigen is recommended for clinical use in the US for ovarian cancer (OC) screening of high risk women with ovaries despite its limited sensitivity and specificity. Recent findings suggest that CA125 might also serve as a predictive marker for pre-invasive OC.
MUC16 (CA125): tumor biomarker to cancer therapy, a work in …
网页2014年5月29日 · CA125 is best known as a biomarker to monitor epithelial ovarian cancer and for the differential diagnosis of pelvic masses [1, 2]. Serum levels of CA125 are routinely monitored in patients with ovarian cancer, and an increase from an individualized nadir concentration is a prognostic indicator of cancer recurrence.
The CA 125 gene: an extracellular superstructure dominated by …
网页The CA 125 protein core is composed of a short cytoplasmic tail, a transmembrane domain and an extraordinarily large glycosylated extracellular structure. This structure is dominated by a repeat domain composed of 156 amino acid repeat units which encompass the epitope binding sites.
Current evidence on CA-125 levels in differentiation between ...
网页5 天之前 · CA-125, a Mucin-16 glycoprotein, often shows elevated levels in patients with ovarian cancer, with a rise observed in around 80% of patients, thus providing evidence for diagnosis. 3–5 However, CA-125 levels may also be elevated in benign conditions, such as endometriosis, which is a chronic and progressive ailment that impacts approximately ...
The Role of CA 125 as Tumor Marker: Biochemical and Clinical …
网页CA 125 also known as mucin 16 or MUC16 is a large membrane glycoprotein belonging to the wide mucin family, encoded by the homonymous MUC16 gene. Following its discovery in the blood of some patients with specific types of cancers or other benign conditions, CA125 has found application as a tumor marker of ovarian cancer.
CA-125 - an overview | ScienceDirect Topics
网页CA-125 is a cell surface antigen and a useful marker in monitoring patients with epithelial ovarian cancer. This antigen is found in coelomic epithelial-derived tissues and thus is also expressed by the endometrium. Elevated CA-125 serum levels were demonstrated in patients with endometriosis especially in advanced stages of the disease.
More than 15 years of CA 125: what is known about the antigen, …
网页Prior to its release from cultured cells, CA 125 is phosphorylated (at either/both serine and threonine) and dephosphorylated when released. To stimulate discussion on the regulation of CA 125 synthesis, its secretion and its structural configuration, we have presented a model of a theoretical CA 125 molecule.
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