CNDAC | 核苷类似物 | MCE - MCE-生物活性分子大师
网页CNDAC 是可口服试剂 Sapacitabine (HY-16445) 的代谢物，为核苷酸类似物。 CNDAC 诱导 DNA 损伤和凋亡 (apoptosis)。 - 高纯度，全球文献引用。
CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant …
网页2019年12月2日 · Incorporation of the clinically active deoxycytidine analogue 2′- C -cyano-2′-deoxy-1-β- D -arabino-pentofuranosyl-cytosine (CNDAC) into DNA generates single-strand breaks that are subsequently converted to double-strand breaks (DSB).
Mechanism-based drug combinations with the DNA-strand …
网页CNDAC (2’- C -cyano-2’-deoxy-1-β-D- arabino -pentofuranosyl-cytosine, DFP10917) and its orally bioavailable prodrug, sapacitabine, are undergoing clinical trials for hematological malignancies and solid tumors. The unique action mechanism of inducing DNA strand breaks distinguishes CNDAC from other deoxycytidine analogs.
TDP1 is Critical for the Repair of DNA Breaks Induced by ... - PubMed
网页2'-C-cyano-2'-deoxy-1-β-d-arabino-pentofuranosylcytosine (CNDAC) is the active metabolite of the anticancer drug, sapacitabine. CNDAC is incorporated into the genome during DNA replication and subsequently undergoes β-elimination that generates single-strand breaks with abnormal 3'-ends.
CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis …
网页Incorporation of the clinically active deoxycytidine analogue 2'-C-cyano-2'-deoxy-1-β-D-arabino-pentofuranosyl-cytosine (CNDAC) into DNA generates single-strand breaks that are subsequently converted to double-strand breaks (DSB). Here, we investigated the cellular manifestations of these breaks that link these mechanisms to cell death, and we ...
CNDAC-induced DNA double strand breaks cause aberrant …
网页Incorporation of the clinically active deoxycytidine analog, 2’-C-cyano-2’-deoxy-1-β-D-arabino-pentofuranosyl-cytosine (CNDAC) into DNA generates single strand breaks that are subsequently converted to double strand breaks (DSBs). Here, we investigated the cellular manifestations of these breaks that link these mechanisms to cell death ...
Targeting BRCA1/2 deficient ovarian cancer with CNDAC-based …
网页In this study, we investigated response of ovarian cancer (OC) cell lines to CNDAC and explored CNDAC-based combination strategies in BRCA1/2 deficient and proficient OC cells. A corollary is that matching the mechanism of action of sapacitabine or CNDAC to the Brca1/2 deficiency in OC may selectively sensitize the tumor.
Mechanism-Based Drug Combinations with the DNA Strand …
网页CNDAC (2'-C-cyano-2'-deoxy-1-β-d-arabino-pentofuranosyl-cytosine, DFP10917) and its orally bioavailable prodrug, sapacitabine, are undergoing clinical trials for hematologic malignancies and solid tumors. The unique action mechanism of inducing DNA strand breaks distinguishes CNDAC from other deoxycytidine analogs.
Targeting BRCA1/2 deficient ovarian cancer with CNDAC …
网页2017年11月30日 · CNDAC is a nucleoside analog with a unique action mechanism of inducing single strand breaks (SSBs) after incorporation into DNA. Incorporated CNDAC is transformed into a de facto chain terminator, CNddC, which is extremely hard to remove [17,18,19]. The SSBs are subsequently converted into double strand breaks (DSBs) during a second S-phase.
2′- C -Cyano-2′-deoxy-1-β-D-arabinofuranosylcytosine (CNDAC): …
网页2007年2月16日 · The antitumor mechanism of action of 2′-C-cyano-2′-deoxy-1-β-d-arabinofuranosylcytosine (CNDAC) has been examined. CNDAC was designed as a potentially DNA-self-strand-breaking nucleoside. It had potent antitumor effects against various solid tumors in vitro as well as in vivo.