肿瘤免疫靶点 | CTLA-4 - 知乎 - 知乎专栏
网页CTLA-4在控制T细胞活化和耐受性中起着至关重要的作用：总的来说一方面 在调节性T细胞（Treg）上介导其免疫抑制能力；另一方面 在静息T细胞活化后表达CTLA-4，作为反馈控制机制，通过调节IFN-γ、T细胞分化、扩张、细胞接触和迁移等细胞因子的产生来平衡适应性免疫反应的强弱。 （数据来源Lingel H, et al. Semin Immunol. 2019） 但是关于CTLA-4如何发挥其抑制作用，仍然存在许多机制性问题。 目前观点主要围绕CTLA-4通过 细胞内在 和 …
CTLA-4 in Regulatory T Cells for Cancer Immunotherapy
网页2021年3月22日 · This review will describe the mechanisms of CTLA-4 immune checkpoint inhibition, the role of T reg cells in tumorigenesis, and how anti-CTLA-4 antibodies can provoke an alteration in the expression of CTLA-4 on T reg cells while exerting anti-cancer therapeutic activity.
Cell | CTLA-4依赖性反馈环的破坏可促进肿瘤相关Treg细胞的过度 …
网页近日， 来自美国麻省综合医院的Thorsten R. Mempel和Francesco Marangoni团队在《Cell》 上在线发表了一篇题为“Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop ”的文章， 研究发现Treg细胞通过CTLA-4和CD28依赖的反馈环自我调节，调节其群体大小以 ...
CTLA-4 blockade drives loss of Treg stability in glycolysis ... - Nature
网页2021年2月15日 · CTLA-4 promotes glucose uptake by tumour-infiltrating regulatory T cells, making them unstable. Limiting metabolic competition in the tumour microenvironment may increase the effectiveness of...
Current understanding of CTLA-4: from mechanism to …
网页2023年7月11日 · In this review, we first describe the structure, expression, and how the signaling pathways of CTLA-4 participate in reducing effector T-cell activity and enhancing the immunomodulatory ability of regulatory T (Treg) cells to reduce immune response, maintain immune homeostasis, and maintain autoimmune silence.
Current Understanding of Cytotoxic T Lymphocyte Antigen-4 (CTLA-4 …
网页2022年8月8日 · Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an immune checkpoint molecule that is mainly expressed on activated T cells and regulatory T (Treg) cells that inhibits T-cell activation and regulates immune homeostasis. Due to the crucial functions of CTLA-4 in T-cell biology, CTLA-4-targeted immunotherapies have been developed for …
Anti-CTLA-4 antibodies drive myeloid activation and reprogram …
网页2022年10月27日 · While antibodies to cytotoxic T lymphocyte-associated protein-4 (CTLA-4) were developed to block inhibitory signals in T cells, several recent studies have demonstrated that Fcγ receptor (FcγR...
聚焦药靶：一文尽览肿瘤免疫治疗分子CTLA-4的研究现状
网页2021年10月18日 · kn-046是康宁杰瑞自主研发的一款可同时靶向pd-l1和ctla-4的双特异性抗体，其创新设计包括采用机制不同的ctla-4与pd-l1单域抗体融合组成，可靶向富集于pd-l1高表达的肿瘤微环境及清除抑制肿瘤免疫的treg。
Treg and CTLA-4: two intertwining pathways to immune tolerance
网页Both the CTLA-4 pathway and regulatory T cells (Treg) are essential for the control of immune homeostasis. Their therapeutic relevance is highlighted by the increasing use of anti-CTLA-4 antibody in tumor therapy and the development of Treg cell transfer strategies for use in autoimmunity and transplantation settings.
Anti-CTLA-4 nanobody as a promising approach in cancer
网页2024年1月8日 · In cancer therapy, two factors play an essential role in generating an effective Anti-CTLA-4 antibody response; one is increasing the expression of CTLA-4 on tumor-associated Treg, and the...
跳至内容