Molecular principles of metastasis: a hallmark of cancer …
网页2020年3月12日 · In patients with cancer, large numbers of cancer cells are released in circulation daily; however, melanoma studies in animal models suggest that <0.1% of tumor cells metastasize. 1 The...
Metastatic Cancer: When Cancer Spreads - NCI - National Cancer …
网页2020年11月10日 · The process by which cancer cells spread to other parts of the body is called metastasis. When observed under a microscope and tested in other ways, metastatic cancer cells have features like that of the primary cancer and not like the cells in the place where the metastatic cancer is found.
Metastasis - Cell Press
网页2023年4月13日 · Metastasis, the growth of cancer cells in organs distant from the one in which they originated, is the ultimate and most lethal manifestation of cancer. The vast majority of cancer patients die as a consequence of …
Targeting metastatic cancer - Nature Medicine
网页2021年1月13日 · Despite recent therapeutic advances in cancer treatment, metastasis remains the principal cause of cancer death. Recent work has uncovered the unique biology of metastasis-initiating cells...
The metabolism of cancer cells during metastasis - Nature
网页2021年1月18日 · The metastatic establishment of cancers at distant organs is largely uncurable and primarily contributes to the deaths of cancer patients. Nonetheless, metastasis formation itself is a rare...
Cancer Invasion and Metastasis: Molecular and Cellular …
网页Cancer metastasis is the spread of cancer cells to tissues and organs beyond where the tumor originated and the formation of new tumors (secondary and tertiary foci) is the single event that results in the death of most patients with cancer.
Mechanisms of cancer metastasis - PubMed
网页Combating cancer metastasis and post-therapeutic recurrence successfully requires understanding each step of metastatic progression. This review describes the current state of knowledge of the etiology and mechanism of cancer progression from primary tumor growth to the formation of new tumors in other parts of the body.
Metastasis: Cancer Cell
网页2022年8月8日 · Metastases are the principal cause of cancer mortality and until recently have been considered to be widespread and require systemic treatment. The oligometastasis hypothesis articulated by Hellman and Weichselbaum suggested a spectrum of metastatic spread, both in metastasis number and pace of progression.
Mechanisms of cancer metastasis - ScienceDirect
网页2022年12月1日 · Combating cancer metastasis and post-therapeutic recurrence successfully requires understanding each step of metastatic progression. This review describes the current state of knowledge of the etiology and mechanism of cancer progression from primary tumor growth to the formation of …
Tumor metastasis: Mechanistic insights and therapeutic …
网页2021年12月2日 · Cancer metastasis is a complex process in which cancer cells escape from the primary tumor, settle and grow at other parts of the body. A variety of stromal cells, immune cells and other molecular components surrounding the tumor provide signals that enhance the metastatic potential of cancer cells.