CoCl2 simulated hypoxia induce cell proliferation and alter the ...
网页2019年3月15日 · HIF-1α dependent BAX expression during hypoxia revealed that after certain extent of hypoxia induction, over expression of BAX conquers the effect of anti-apoptotic proteins and ultimately leads to apoptosis in breast cancer cells.
The Effects of CoCl2 on HIF-1α Protein under Experimental …
网页2014年6月18日 · It is well known that cobalt chloride (CoCl 2) can enhance the stability of hypoxia-inducible factor (HIF)-1α. The aim of this study is to detect the effect of CoCl 2 on the hypoxia tolerance of mice which were repeatedly exposed to autoprogressive hypoxia.
The effects of CoCl2 on HIF-1α protein under experimental
网页2014年6月18日 · It is well known that cobalt chloride (CoCl2) can enhance the stability of hypoxia-inducible factor (HIF)-1α. The aim of this study is to detect the effect of CoCl2 on the hypoxia tolerance of mice which were repeatedly exposed to autoprogressive hypoxia.
CoCl2 increases the expression of hypoxic markers HIF-1α, VEGF …
网页2017年11月8日 · To examine further whether hypoxia affects the protein expression of HIF-1α, CXCR4 and VEGF, levels were examined by western blotting in MCF-7 cells cultured for 48 h with different CoCl 2 concentrations. The expression of HIF-1α protein significantly increased following treatment with CoCl 2 (150 µM; P<0.05; Fig. 1B).
Differential response to CoCl2-stimulated hypoxia on HIF-1α
网页In this study, we investigated the differential response of ACL and MCL fibroblasts to hypoxia on hypoxia-inducible factor-1α, vascular endothelial growth factor, and matrix metalloproteinase-2 (MMP-2) expression. Our results show that ACL cells responded to hypoxia by up-regulating the HIF-1α expression significantly as compared to MCL cells.
CoCl2, a chemical inducer of hypoxia-inducible factor-1, and …
网页CoCl2 reduced the apoptotic death of HepG2 cells induced by t-BHP and serum deprivation, as measured by DNA fragmentation. This effect was confirmed by measurement of the caspase activity. Moreover, hypoxia also prevented t-BHP- or serum deprivation-induced DNA fragmentation and caspase activation-however, to a lower extent than CoCl2.
The Effects of CoCl2 on HIF-1α Protein under Experimental ... - MDPI
网页2014年6月18日 · It is well known that cobalt chloride (CoCl 2) can enhance the stability of hypoxia-inducible factor (HIF)-1α. The aim of this study is to detect the effect of CoCl 2 on the hypoxia tolerance of mice which were repeatedly exposed to autoprogressive hypoxia.
HIF-1α/FOXO1 axis regulated autophagy is protective for β cell …
网页2022年5月1日 · HIF-1α promotes the transcription of FOXO1 in β cells in CoCL2-mimicked hypoxia. • HIF-1α/Foxo1 signaling accelerates autophagy and protects β cell survival. • β cells have the highest expressions of LC3 and p62 in human islets under hypoxia. • LC3 and p62 expressions are negatively associated with HbA1c. •
CoCl2, a Chemical Inducer of Hypoxia‐Inducible Factor‐1, and …
网页2006年1月24日 · ARNT is constitutively expressed, whereas HIF-1α is targeted to proteasome degradation by ubiquitination during normoxia. In hypoxia, HIF-1α is stabilized and translocates to the nucleus, where it binds to ARNT. The active HIF-1 induces expression of various genes whose products play an adaptive role to the new conditions induced by hypoxia.
缺氧和 HIF-1α 保护 A549 细胞免受药物诱导的细胞凋亡
网页2006年2月3日 · 此外，缺氧模拟物 CoCl2，稳定 HIF-1a 并激活 HIF-1，促进耐药性，尽管与缺氧相比，保护作用不那么突出。 CoCl2 诱发的保护在 HIF-1a 敲低后被消除，表明 HIF-1 的特异性作用（图 1C）。