Antigen presentation by dendritic cells and their instruction of CD4…
网页2020年5月20日 · DC are the primary antigen-presenting cell population in vivo and are essential to elicit antigen-specific activation and expansion of naive CD4+ T cells though the peptide–MHCII interaction ...
Immunity | 树突状细胞(DCs)在肿瘤中作为T细胞免疫的"牧羊人"
网页2023年10月14日 · DC在肿瘤内的发展需要一个支持的活性环境，这至少部分是由Flt3L、XCL1、CCL5和IFN-g驱动的，它们可以由各种细胞类型产生，包括自然杀伤(NK)细胞。后者可在免疫原性肿瘤细胞死亡后被钙调蛋白激活。I型干扰素的释放也可以触发支持dc的环境。
树突状细胞-DC细胞是什么-赛默飞免疫学资源 | Thermo Fisher …
网页树突状细胞（DC细胞）在天然性免疫系统中识别病原体，在适应性免疫系统中激活免疫细胞。. 在这里，DC细胞通过MHC分子呈递抗原肽来诱导Naïve T细胞激活和分化，意味着启动了适应性免疫系统；随后，DC细胞继续诱导效应性T细胞分化和调节T细胞的耐受性。. 不 ...
CD4 + T Cells: Differentiation and Functions - National Center for ...
网页2012年3月14日 · CD4 + T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4 + T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the microenvironment.
Dendritic cells as orchestrators of anticancer immunity and
网页2024年2月7日 · Dendritic cells (DCs) can induce adaptive anticancer immunity mainly via uptake and presentation of tumour-associated antigens, migration to lymph nodes and T cell priming, and...
Human dendritic cell subsets: an update - PMC - National Center …
网页2018年2月27日 · Dendritic cells (DC) are a class of bone‐marrow‐derived cells arising from lympho‐myeloid haematopoiesis that form an essential interface between the innate sensing of pathogens and the activation of adaptive immunity.
cDC1 prime and are licensed by CD4 - Nature
网页2020年8月12日 · Conventional type 1 dendritic cells (cDC1) 1 are thought to perform antigen cross-presentation, which is required to prime CD8 + T cells 2, 3, whereas cDC2 are specialized for priming CD4 + T ...
另辟蹊径！CD4+T细胞谱写肿瘤免疫新篇章！ - 知乎专栏
网页cd4+t细胞——肿瘤免疫不可或缺的重要角色. cd4+t细胞是人体免疫系统中的一种重要免疫细胞，cd4 主要表达于辅助t（th）细胞，可与mhcⅡ类分子的非多肽区结合，参与t细胞抗原受体（tcr）识别抗原的信号转导。
Correction of age-associated defects in dendritic cells enables CD4
网页2024年7月25日 · When administered early in life, DC hyperactivators were the only adjuvant identified that elicited anti-tumor CD4 + T cells that persisted into old age. These results raise the possibility of correcting age-associated immune defects through DC manipulation.
Frontiers | Human Dendritic Cells: Their Heterogeneity and Clinical ...
网页2019年1月21日 · CD4+ T cell fate induced by dendritic cells. When in contact with DC, naïve CD4+ T cells can differentiate into a number of subtypes. Among them, are regulatory T cells (Treg) and T helper (Th) subsets, which include Th1, Th2, and Th17 cells.
跳至内容