Donepezil - StatPearls - NCBI Bookshelf
网页2023年8月17日 · Donepezil is an FDA-approved medication used for the treatment of dementia in mild, moderate, and severe Alzheimer disease. [1] [2] Although there is currently no evidence to suggest that donepezil can alter the progression of the disease, it can improve cognition and behavior, thereby alleviating certain symptoms.
Donepezil: Uses, Interactions, Mechanism of Action - DrugBank …
网页Donepezil is an acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia.
Donepezil Uses, Dosage, Side Effects, Warnings - Drugs.com
网页2024年7月4日 · Donepezil improves the function of nerve cells in the brain and works by preventing the breakdown of a chemical called acetylcholine (ah SEET il KOE leen). People with dementia usually have lower levels of this chemical, which is important for memory, thinking, and reasoning.
Donepezil - Wikipedia
网页In addition to its actions as an acetylcholinesterase inhibitor, donepezil has been found to act as a potent agonist of the σ 1 receptor (K i = 14.6 nM), and has been shown to produce specific antiamnestic effects in animals mainly via this action.
Donepezil: MedlinePlus Drug Information
网页Donepezil is used to treat dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) in people who have Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle ...
Donepezil - Uses, Side Effects, and More - WebMD
网页2024年8月7日 · Donepezil is commonly used to treat mild, moderate, and severe dementia related to Alzheimer’s disease. Donepezil may also be used for other conditions as determined by your healthcare...
Donepezil: Dosage, Mechanism/Onset of Action, Half-Life
网页Mechanism of Action. Alzheimer's disease is characterized by cholinergic deficiency in the cortex and basal forebrain, which contributes to cognitive deficits. Donepezil reversibly and noncompetitively inhibits centrally-active acetylcholinesterase, the enzyme responsible for hydrolysis of acetylcholine.
Donepezil in Alzheimer’s disease: From conventional trials to ...
网页Donepezil is the number one member of the second generation of acetylcholinesterase inhibitors (AChEIs) (ie, donepezil, rivastigmine, galantamine) (Table 1) developed for the treatment of Alzheimer’s disease (AD) after the postulation in the early 1980s that AD was associated with a central cholinergic deficit (Bartus et al 1982; Whitehouse ...
Donepezil: A Review of Pharmacological Characteristics and Role …
网页2010年9月20日 · Donepezil is a potent, selective, noncompetitive, and rapidly reversible inhibitor of acetylcholinesterase (AChEI) licensed for the treatment of Alzheimer disease (AD); and is the first and only AChEI licensed for the treatment of severe AD.
Donepezil - PubMed
网页2023年8月17日 · Donepezil hydrochloride, a piperidine derivative, is a centrally acting, rapid, and reversible acetylcholinesterase inhibitor primarily utilized for treating Alzheimer disease. Acetylcholinesterase is an enzyme that breaks down acetylcholine after its release from the presynapse.
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