Donepezil - StatPearls - NCBI Bookshelf
网页2023年8月17日 · Donepezil is an FDA-approved medication used for the treatment of dementia in mild, moderate, and severe Alzheimer disease. [1] [2] Although there is currently no evidence to suggest that donepezil can alter the progression of the disease, it can improve cognition and behavior, thereby alleviating certain symptoms.
Donepezil: Uses, Interactions, Mechanism of Action - DrugBank …
网页Donepezil is an acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia.
Donepezil - Wikipedia
网页Donepezil, sold under the brand name Aricept among others, is a medication used to treat dementia of the Alzheimer's type. [3] [4] [8] It appears to result in a small benefit in mental function and ability to function. [9] Use, however, has not been shown to change the progression of the disease. [10] Treatment should be stopped if no benefit ...
Donepezil: Dosage, Mechanism/Onset of Action, Half-Life
网页Generic: 5 mg, 10 mg. Pharmacology. Mechanism of Action. Alzheimer's disease is characterized by cholinergic deficiency in the cortex and basal forebrain, which contributes to cognitive deficits. Donepezil reversibly and noncompetitively inhibits centrally-active acetylcholinesterase, the enzyme responsible for hydrolysis of acetylcholine.
Donepezil - PubMed
网页2023年8月17日 · Donepezil hydrochloride, a piperidine derivative, is a centrally acting, rapid, and reversible acetylcholinesterase inhibitor primarily utilized for treating Alzheimer disease. Acetylcholinesterase is an enzyme that breaks down acetylcholine after its release from the presynapse.
Donepezil: A Review of Pharmacological Characteristics and Role …
网页2010年9月20日 · Donepezil is a potent, selective, noncompetitive, and rapidly reversible inhibitor of acetylcholinesterase (AChEI) licensed for the treatment of Alzheimer disease (AD); and is the first and only AChEI licensed for the treatment of severe AD.
Donepezil in Alzheimer’s disease: an evidence-based review of …
网页2006年3月31日 · There is evidence that donepezil has efficacy against the three major domains of Alzheimer’s disease symptoms, namely functional ability, behavior, and cognition. The strongest evidence is for improvement or less deterioration in global outcomes and cognition in the short to medium term.
Donepezil | C24H29NO3 | CID 3152 - PubChem
网页Donepezil is a racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine .
Donepezil: an update - PubMed
网页Donepezil hydrochloride is the most widely prescribed drug for Alzheimer's disease (AD). The main mechanism of action through which it influences cognition and function is presumed to be the inhibition of acetylcholinesterase enzyme in the brain; however, donepezil may also impact the pathophysiolog ….
Donepezil (Aricept) - SpringerLink
网页2019年10月25日 · Donepezil is a symptomatic drug for Alzheimer’s disease that was discovered and developed by Eisai Co., Ltd. It has a temporary suppressive effect on the pathology of Alzheimer’s disease. Donepezil increases the concentration of acetylcholine, a key neurotransmitter in the brain, by inhibiting the degradative enzyme acetylcholinesterase.
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