Global Cancer Drug Development—A Report From the 2022 …
网页2023年11月9日 · Examining central themes of affordability, accessibility, and equity, we discuss barriers and opportunities to increase cancer drug development and clinical trials and access to treatment in LMICs, with a particular focus on Africa and Latin America.
A standing platform for cancer drug development using ctDNA …
网页2024年9月30日 · Here, we envision a way to accelerate cancer drug development via the creation of a standing cancer clinical trials platform, in which many patients across geographic regions would be ...
Understanding the Path to Cancer Development - Cancer …
网页This knowledge has led to improvements in the prevention of cancer, development of innovative imaging technologies, precise delivery of drugs to tumors, and selective and effective killing of cancer cells.
3D bioprinted cancer models: from basic biology to drug development
网页2022年10月24日 · 3D bioprinted cancer models have the potential to revolutionize the way we study, diagnose, prevent and treat cancer. The commercialization of such models specifically in the drug...
Accelerating anticancer drug development — opportunities …
网页2018年10月1日 · The authors describe several opportunities to improve the efficiency of drug development in oncology, as well as new mechanisms to obtain information about anticancer therapies throughout their...
Challenges and opportunities in oncology drug development and …
网页2024年3月28日 · In particular, China faces a substantial burden, with the highest numbers of new cases (4.57 million) and deaths (3 million) accounting for 23.7% and 30%, respectively, of the world’s total population. 1 Hence, the increasing prevalence of cancer in China has created a pressing demand for effective therapeutic solutions.
网页Presentations in the AAADV session highlighted many key barriers to cancer drug development and access to cancer medicines in LMICs, which we classify into three broad categories: (1) lack of diagnostic services, human resources, and weak health system infrastructure; (2) barriers in drug access and affordability; and (3) barriers in research in...
Cancer Development, Progression, and Therapy: An Epigenetic …
网页2013年10月21日 · The new paradigm of drug development involves targeting multiple hallmarks of cancer simultaneously. We have proposed that exposure to epigenetic and non-epigenetic drugs which re-express tumor suppressor genes should sensitize the cancer cells to lower doses of traditional cytotoxic drugs [ 5 ].
A recent development of new therapeutic agents and novel drug …
网页2021年12月23日 · Several obstacles stand in the way of effective cancer treatment and drug development, including inaccessibility of tumor site by appropriate drug concentration, debilitating untoward effects caused by non-selective tissue distribution of chemotherapeutic agents, and occurrence of drug resistance, which leads to cross-resistance to a variety of ...
Pursuing breakthroughs in cancer-drug development | McKinsey
网页2018年1月12日 · Pioneering examples of these innovative development paradigms include, but are not limited to, pembrolizumab (KEYNOTE-001 supported the initial registration in both NSCLC and melanoma as a Phase I trial), osimertinib (followed the accelerated-approval path as a breakthrough therapy with a single-arm design), and LOXO-101 (announced plans to subm...