The ECM-cell interaction of cartilage extracellular matrix on ...
网页Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen (COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic acid (HA), and chondroitin sulfate (CS). Articular cartilage ECM plays a crucial role in regulating chondrocyte metaboli ….
Mechanosignalling in cartilage: an emerging target for the ... - Nature
网页2021年12月21日 · In cartilage, chondrocytes synthesize, and are surrounded by, a highly specialized extracellular matrix (ECM) that enables low friction movement and protects the tissue during mechanical loading...
Matrix stiffening promotes chondrocyte senescence and the ...
网页2024年5月24日 · We found that ECM stiffening accelerated cultured chondrocyte senescence in vitro, while the stiffness ECM downregulated HDAC3, prompting Parkin acetylation to activate excessive mitophagy...
The regulation of cartilage extracellular matrix homeostasis in …
网页2020年11月24日 · Altogether, the proper functioning of extensive cartilage ECM components provides the chondrocytes with survival and proliferative signals, forming a niche for chondrocyte metabolism. These studies illustrate how the ECM regulates metabolic homeostasis and suggest that the ECM niche maintenance may be therapeutically beneficial in ...
Mitophagy as a link between ECM stiffness and chondrocyte
网页2024年6月21日 · Cartilage degeneration in OA involves a senescent phenotype of chondrocytes, as well as modifications of the extracellular matrix (ECM). Research published in Bone Research investigates how...
The Extracellular Matrix of Articular Cartilage Controls the ...
网页2022年5月26日 · By volume, the ECM makes up around 90% of the tissue, with chondrocytes, the principal cell type in cartilage, contributing only 5–10% to tissue volume. Cartilage is devoid of blood vessels and nerves; thus, responses in the tissue are mediated by the chondrocytes alone, and presumably by mainly non-paracrine effects as the cells are ...
The ECM-Cell Interaction of Cartilage Extracellular Matrix on ...
网页2014年5月18日 · In terms of biomechanics, cartilage tissue can remodel its ECM in response to alterations in functional demand. The pericellular matrix (PCM) is a narrow tissue region surrounding chondrocytes in articular cartilage, which together with the enclosed cell (s) has been termed the “chondron” [8].
Extracellular matrix derived from chondrocytes promotes rapid expansion ...
网页2019年2月1日 · We hypothesized that chondrocyte extracellular matrix (ECM) mimics a native microenvironment and that it may support chondrocyte expansion in vitro. To test this hypothesis, we prepared decellularized ECMs from allogeneic human articular chondrocytes (HAC) (AC-ECM) and bone marrow stromal cells (BM-ECM) and studied their effects on the in vitro ...
Chondrocyte Homeostasis and Differentiation: Transcriptional …
网页2023年6月28日 · Chondrocytes are the main cell type in articular cartilage. They are embedded in an avascular, abundant, and specialized extracellular matrix (ECM). Chondrocytes are responsible for the synthesis and turnover of the ECM, in which the major macromolecular components are collagen, proteoglycans, and non-collagen proteins.
Chondrocyte Ferritinophagy as a Molecular Mechanism of
网页3 天之前 · Ferroptosis is a novel form of iron-dependent cell death. Iron death affects the progression of OA by interacting with lipid peroxidation, oxidative stress, and inflammation, resulting in synovitis, articular cartilage degeneration, and structural disruption of the ECM, which regulates articular chondrocyte and matrix homeostasis. . Ferroptosis ...