What is DMPK? | JSSX
网页What is DMPK? Drug Metabolism and Pharmacokinetics (DMPK ) is an English-language journal published by the Japanese Society of Pharmacokinetics (JSSX), and publishes highly original articles on basic and applied research on pharmacokinetics, metabolism, transporters, DDS, clinical pharmacology, analysis, gene expression, and pharmacogenetics of ...
Myotonin-protein kinase - Wikipedia
网页Dystrophia myotonica protein kinase (DMPK) is a serine/threonine kinase composed of a kinase domain and a coiled-coil domain involved in the multimerization. The crystal structure of the kinase domain of DMPK bound to the inhibitor bisindolylmaleimide VIII (BIM-8) revealed a dimeric enzyme associated by a conserved dimerization domain.
DruMAP: A Novel Drug Metabolism and Pharmacokinetics Analysis …
网页2023年7月14日 · We developed a novel drug metabolism and pharmacokinetics (DMPK) analysis platform named DruMAP. This platform consists of a database for DMPK parameters and programs that can predict many DMPK parameters based on the chemical structure of a compound.
DMPK Services - Pharmaron
网页Pharmaron’s DMPK group offers comprehensive in vitro ADME, radiolabelled metabolism, in vitro toxicity and in vivo pharmacokinetics services, which allow for the evaluation of DMPK properties and toxicity of small molecule drug candidates with high data quality in a cost-effective manner.
Recent advances in the translation of drug metabolism and ...
网页2022年6月1日 · The new modalities, which, with increasing complexity and diversity, have revolutionized the treatment of a wide range of diseases, such as cancer, neurodegenerative disorders, and autoimmune diseases, require more comprehensive preclinical DMPK tools. Here we highlight several DMPK advancements …
The role of DMPK science in improving pharmaceutical research …
网页2022年3月1日 · DMPK is a core discipline in the drug discovery and development process with a vital role in confirming which drug candidate might advance into the clinical development stage. The purpose of DMPK studies is to determine the absorption, distribution, metabolism, excretion, and toxicity (ADME/T) properties and pharmacokinetics (PK) of a drug ...
Myotonic dystrophy protein kinase (DMPK) prevents ROS-induced …
网页2013年10月17日 · Down-modulation of DMPK abolishes the appearance of muscle markers in in vitro myogenesis, which is rescued by oxidant scavenging.
The Perspective of DMPK on Recombinant Adeno-Associated
网页2022年1月31日 · In this review, based on the learnings from Takeda and publicly available information, we aim to provide a guiding perspective on Drug Metabolism and Pharmacokinetics (DMPK) substantial role in advancing therapeutic gene therapy modalities from nonclinical research to clinical development, in particular the …
Fundamental aspects of DMPK optimization of targeted
网页2020年6月1日 · In this review we discuss our experience of these DMPK optimization challenges and present methodologies and strategies to overcome the hurdles dealing with this new small-molecule modality, specifically in developing oral degraders to treat cancer.
网页Abstract This section addresses some typical DMPK questions that an ADME scientist encounters during drug discovery support. These questions are addressed by means of general concepts, experimental approaches, and examples. They are also linked to other sections for the ease of search and understanding.