Hydrogel-based matrices for controlled drug delivery of etamsylate ...
网页2020年11月6日 · Etamsylate is a hemostatic and non-thrombogenic drug used for treatment and prevention of pre-, per-, or post-surgical capillary hemorrhage (Garay et al., 2006). It acts by inhibition of Prostacyclin I2 synthesis which is responsible for platelet disaggregation (Schulte et al., 2005).
Spatiotemporally Controlled Release of Etamsylate from …
网页2024年7月10日 · Achieving rapid clotting and clot stability are important unmet goals of clinical management of noncompressible hemorrhage. This study reports the development of a spatiotemporally controlled release system of an antihemorrhagic drug, etamsylate, in the management of internal hemorrhage.
Physiologically relevant model to establish the in vivo-in vitro ...
网页2021年12月1日 · Etamsylate, an antihemorrhagic agent, was utilized as a model drug. It is a highly soluble drug [[4], [5]]. The bioavailability of etamsylate is close to 100% with a considerable fast intestinal absorption [4, 6]. Etamsylate is excreted mainly unchanged in the urine and no metabolites were detected [4].
Recent developments in chemical conjugation strategies targeting native ...
网页Isocyanate reacts readily with an amino group to yield a stable urea linkage, and this reaction is widely exploited in the elastomer industry, not just in bioconjugation. 73 Isocyanate's high reactivity towards proteins is confirmed with its reaction with albumins or keratins in the airway, which is known to be a cause of allergic respiratory ...
Orthogonal bioconjugation targeting cysteine-containing …
网页2024年8月12日 · This “two steps, one pot” bioconjugation method is successfully applied to label bovine serum albumin. Therefore, our technique is a versatile and powerful tool for late-stage orthogonal ...
Enzymatic Bioconjugation: A Perspective from the Pharmaceutical ...
网页2023年5月4日 · In this Perspective, we seek to illuminate applications of enzymatic bioconjugation in the face of an expanding palette of new drug modalities. With these applications, we wish to highlight some examples of current successes and pitfalls of using enzymes for bioconjugation along the pipeline and try …
Full article: Bioconjugation as a smart immobilization approach …
网页2019年6月13日 · Bio-inspired Eudragit-α-amylase conjugate (E-AC) was proposed as a biocatalyst for various pharmaceutical and industrial applications. In this study, α -Amylase (E.C. 3.2.1.1) was immobilized by covalent conjugation …
Hydrogel-based matrices for controlled drug delivery of etamsylate ...
网页Objectives: To design oral controlled release (CR) hydrogel matrix tablets of etamsylate using various hydrophilic polymers. Additionally, to predict plasma concentration-time profiles of etamsylate released from different CR matrices.
Bioconjugate Chemistry: Enabling Innovation and Fostering …
网页2022年12月23日 · In this topical review, we summarize selected recent advances in bioconjugation strategies for the development of therapeutic conjugates, their emerging application in clin. settings, as well as perspectives on the direction of future research.
An efficient system for bioconjugation based on a widely …
网页2021年11月16日 · ABSTRACT. Bioconjugates are an important class of therapeutic molecules.