NON-HNSCC SOLID TUMORS IN PATIENTS WITH FANCONI ANEMIA
网页Cancer risk and management is a major concern for patients with Fanconi anemia (FA) due to the DNA repair defects associated with the disease. The most frequently diagnosed solid tumor cancers in FA patients include head and neck squamous cell carcinoma (HNSCC) and gynecologic squamous cell carcinoma (SCC).
An update on Fanconi anemia: Clinical, cytogenetic and molecular ...
网页2021年7月15日 · Fanconi anemia is a genetic syndrome clinically characterized by congenital malformations that affect several human systems, leads to progressive bone marrow failure and predisposes an individual to cancer, particularly in the urogenital area as well as the head and neck.
HEAD AND NECK CANCER IN PATIENTS WITH FANCONI ANEMIA
网页Head and neck squamous cell carcinoma (HNSCC) is significantly more common in patients with Fanconi anemia (FA) than in the general population. This chapter provides an overview of HNSCC in patients with FA. Focus areas include early surveillance, risk factors, diagnosis, and currently available treatment options.
Clinical Care - Fanconi Cancer Foundation
网页Chapter 1 The Fanconi Anemia DNA Repair Pathway. Chapter 2 Diagnosis of Fanconi Anemia: Testing and Genetic Counseling. Chapter 3 Clinical Care of Fanconi Anemia Hematologic Issues. Chapter 4 Non-HNSCC Solid Tumors in Patients with Fanconi Anemia. Chapter 5 Head and Neck Cancer in Patients with Fanconi Anemia.
Fanconi Anemia - GeneReviews® - NCBI Bookshelf
网页2002年2月14日 · The primary clinical features of Fanconi anemia (FA) include physical features, progressive bone marrow failure manifest as pancytopenia, and cancer susceptibility; however, some individuals with FA have neither physical abnormalities nor bone marrow failure.
Genotype-phenotype and outcome associations in patients with Fanconi …
网页2023年1月1日 · Fanconi anemia (FA) is caused by pathogenic variants in the FA/BRCA DNA repair pathway genes, and is characterized by congenital abnormalities, bone marrow failure and an increased risk of cancer. We conducted a genotype-phenotype and outcomes study of 203 patients with FA in our cohort.
Treatment of Fanconi Anemia–Associated Head and Neck Cancer ...
网页2021年10月1日 · Although patients with Fanconi anemia are at high risk for many hematologic and solid malignancies, the proclivity for mucosal squamous cell carcinomas (SCC), especially head and neck SCC (HNSCC), is particularly striking.
Fanconi anaemia and cancer: an intricate relationship
网页2018年1月29日 · An altered Fanconi anaemia (FA) pathway (also known as the FA–BRCA pathway) causes genomic instability and cancer in humans — from the eponymous inherited bone marrow failure (BMF) disorder ...
Modern management of Fanconi anemia - American Society of …
网页2022年12月9日 · Fanconi anemia (FA) is a rare, multisystem, genetic disorder, characterized by bone marrow failure (BMF); somatic malformations; cancer predisposition, mainly for acute myeloid leukemia (AML) and epithelial cancers of the head and neck; and exquisite sensitivity to proinflammatory cytokines and alkylating agents. 1, 2.
Fanconi anaemia and cancer: an intricate relationship - PubMed
网页Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure (BMF), developmental abnormalities and predisposition to cancer. Together with other proteins involved in DNA repair processes and cell division, the FA proteins maintain genome homeostasis, and germline mutation ….