HIV protease inhibitors: a review of molecular selectivity and …
网页2015年4月8日 · A large number of solved HIV protease protein structures have greatly facilitated the design of new and improved inhibitors. There are ten HIV protease inhibitors approved by the FDA; those inhibitors include: saquinavir, indinavir, ritonavir, nelfinavir, amprenavir, fosamprenavir, lopinavir, atazanavir, tipranavir, and darunavir (Figure 2 ...
Protease inhibitor (pharmacology) - Wikipedia
网页Protease inhibitors (PIs) are medications that act by interfering with enzymes that cleave proteins. Some of the most well known are antiviral drugs widely used to treat HIV/AIDS, hepatitis C and COVID-19.
HIV: Guide to Protease Inhibitors - Healthline
网页2023年6月1日 · Protease inhibitors are one type of antiretroviral drug used to treat HIV. Their goal is to reduce the amount of HIV virus in the body to levels that are...
HIV Protease: Historical Perspective and Current Research
网页2021年5月6日 · This review covers the historical background of studies on the structure and function of HIV protease, the subsequent development of antiviral inhibitors, and recent studies on drug-resistant protease variants.
What to Start: Protease Inhibitor–Based Regimens | NIH
网页2024年9月12日 · View the characteristics and recommendations for the initial use of protease inhibitors (PIs) in adults and adolescents with HIV.
Recent Progress in the Development of HIV-1 Protease Inhibitors …
网页2016年6月6日 · HIV-1 protease inhibitors continue to play an important role in the treatment of HIV/AIDS, transforming this deadly ailment into a more manageable chronic infection. Over the years, intensive research led to a variety of approved protease inhibitors for the treatment of HIV/AIDS.
HIV protease inhibitors: a review of molecular selectivity and
网页2015年4月8日 · From the chemical structures of HIV protease inhibitors and their possible off-target molecules, we could obtain hints for optimizing the molecular selectivity of the inhibitors, to provide help in the design of new compounds with enhanced bioavailability and reduced side effects.
Single atom changes in newly synthesized HIV protease inhibitors …
网页2020年6月30日 · HIV-1 protease inhibitors (PIs), such as darunavir (DRV), are the key component of antiretroviral therapy. However, HIV-1 often acquires resistance to PIs.
Protease inhibitors give wings to combination therapy - Nature
网页2018年11月28日 · The addition of an orally administered protease inhibitor, the first of which was approved in 1995, reduced HIV plasma concentrations and increased CD4 + cell counts to levels that enabled...
hiv-protease-inhibitors - UpToDate
网页Switching antiretroviral therapy for adults with HIV-1 and a suppressed viral load … nephrotoxicity compared with TDF, and ritonavir -boosted darunavir is generally better tolerated than other protease inhibitors (PIs), including boosted atazanavir .