Defensins and Other Antimicrobial Peptides and Proteins
网页2007年5月9日 · HNP-3 crystallizes as a dimer that configures a six-stranded β-sheet stabilized by hydrophobic interactions and hydrogen bonds. That the invariant glycine 18 is located at the dimer interface suggests that dimer formation may be an essential element of defensin-mediated activity.
Lumbar Herniated Nucleus Pulposus - MSD Manuals
网页Key Points. Herniated nucleus pulposus is prolapse of an intervertebral disk through a tear in the surrounding annulus fibrosus. The tear causes pain due to irritation of sensory nerves in the disk, and when the disk impinges on an adjacent nerve root, a segmental radiculopathy with paresthesias and weakness in the distribution of the affected ...
中性粒细胞防御素与肺部疾病的研究进展 - 丁香园
网页hnps 抗革兰阳性菌（金黄色葡萄球菌）效应表现为 hnp-2 ＞ hnp-1 ＞ hnp-3 ＞ hnp-4 ，而抗革兰阴性菌（大肠杆菌）效应表现为 hnp-4 ＞ hnp-2 ＞ hnp-1—hnp3 。 HNP1 和 HNP2 可以诱导甲型流感病毒的聚集并增加中性粒细胞摄取甲型流感病毒。
Nucleus Pulposus Herniation - StatPearls - NCBI Bookshelf
网页2023年8月7日 · This activity describes the etiology, epidemiology, clinical presentation and treatment of a nucleus pulposus herniation, which is a condition characterized by a rupture of the annulus fibrosus with a displacement of the nucleus pulposus outside the intervertebral disc space causing symptoms derived …
DEFA3 protein expression summary - The Human Protein Atlas
网页Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a …
Crystal Structure of Defensin HNP-3, an Amphiphilic Dimer ... - Science
网页1991年3月22日 · The high-resolution crystal structure of defensin HNP-3 (1.9 angstrom resolution, R factor 0.19) reveals a dimeric β sheet that has an architecture very different from other lytic peptides. The dimeric assembly suggests mechanisms by which defensins might bind to and permeabilize the lipid bilayer.
Defensin HNP-3 human | 防御素 | MCE - MCE-生物活性分子大师
网页Defensin HNP-3 human is a cytotoxic antibiotic peptide known as "defensin". Defensin HNP-3 human has inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli.
Human Antimicrobial Peptides and Proteins - PMC - National …
网页2014年5月13日 · Based on the source, property and size, these peptides were named as human neutrophil peptides (HNP-1, HNP-2, and HNP-3). The three defensins have nearly identical amino acid sequences (Table 1). Compared to HNP-2, both HNP-1 and HNP-3 contain only one additional amino acid residue at the N-terminus: alanine for HNP-1 and aspartate for HNP-3.
Study of the Interaction of Human Defensins with Cell Membrane …
网页2007年9月5日 · The HNP-1, HNP-2, and HNP-3 defensins are human antimicrobial peptides produced in response to microbial invasion. Their properties are distinct, with a more potent action for HNP-3. In this study, the relationship between their structural dissimilarities and their different microbial actions was evaluated by molecular dynamics simulation.
HNP-3 enhanced the antimicrobial activity of CIP by promoting …
网页To establish a novel strategy of P. aeruginosa control, we acquired recombination HNP-3 by gene recombination. Then we examined HNP-3 bio-activities and the influences of antimicrobial peptide on the efflux of ATP. Consequently, we obtained target protein with a molecular mass of 3,000 D consistent with the Anticipation.