Histone - Wikipedia
网页Histones prevent DNA from becoming tangled and protect it from DNA damage. In addition, histones play important roles in gene regulation and DNA replication. Without histones, unwound DNA in chromosomes would be very long. For example, each human cell has about 1.8 meters of DNA if completely stretched out; however, when wound about histones ...
Histone - National Human Genome Research Institute
网页2 天之前 · A histone is a protein that provides structural support for a chromosome. Each chromosome contains a long molecule of DNA, which must fit into the cell nucleus. To do that, the DNA wraps around complexes of histone proteins, giving the chromosome a more compact shape. Histones also play a role in the regulation of gene expression.
组蛋白 - 百度百科
网页组蛋白（histone）是真核生物体细胞染色质与原核细胞中的碱性蛋白质，和DNA共同组成核小体结构。. 它们是染色质的主要蛋白质组分，作为DNA缠绕的线轴，并在基因调控中发挥作用，但是原核细胞组蛋白对基因调控的作用非常微弱。. 没有组蛋白，染色体中未 ...
Histones and histone variant families in prokaryotes
网页2024年9月11日 · Histones are important chromatin-organizing proteins in eukaryotes and archaea. They form superhelical structures around which DNA is wrapped. Recent studies have shown that some archaea and ...
histone / histones | Learn Science at Scitable - Nature
网页Histones are a family of basic proteins that associate with DNA in the nucleus and help condense it into chromatin. Nuclear DNA does not appear in free linear strands; it is highly condensed and...
Histone | DNA, Chromatin & Proteins | Britannica
网页histone, any of a group of simple alkaline proteins usually occurring in cell nuclei, combined ionically with DNA (deoxyribonucleic acid) to form nucleoprotein s (q.v.). A unit in which a molecule of a histone is bound to a segment of the DNA chain of genetic material is …
The roles of histone variants in fine-tuning chromatin ... - Nature
网页2020年7月14日 · Histone variants are characterized by a distinct protein sequence and a selection of designated chaperone systems and chromatin remodelling complexes that regulate their localization in the...
A focus on the roles of histones in health and diseases
网页2021年8月1日 · Histones are small basic proteins that have been studied for many years and were initially described as packaging proteins because they are responsible for compacting and organizing the DNA into structural units called nucleosomes.
Histones: At the Crossroads of Peptide and Protein Chemistry
网页2014年10月20日 · In the context of histones, the ability to genetically encode residues containing PTMs has been tremendously useful. In particular, acetyllysine can be integrated into ribosomal protein synthesis using an engineered aaRS originally dedicated to pyrrolysine in Methanosarcina barkeri.
What Are Histones? An Overview - The Lifesciences Magazine
网页Histones serve as the foundational building blocks of chromatin, the dynamic structure that packages and protects DNA within the cell nucleus. The core histones – H2A, H2B, H3, and H4 – assemble to form an octameric structure known as the nucleosome, around which DNA elegantly winds.