KRAS - Wikipedia
网页KRAS (Kirsten rat sarcoma virus) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature and take on specialized functions (differentiate).
KRAS mutation: from undruggable to druggable in cancer
网页2021年11月15日 · Kirsten rat sarcoma viral oncogene homologue (KRAS) is the best-known oncogene with the highest mutation rate among all cancers and is associated with a series of highly fatal cancers,...
Targeting the KRAS mutation for more effective cancer …
网页2021年2月12日 · What is KRAS? How do mutations in KRAS lead to cancer? In healthy cells, KRAS serves as an on-off switch that regulates cell growth. It does this by binding a KRAS-activating molecule called GTP and then converts it …
What’s new in KRAS mutation research? - MD Anderson Cancer …
网页2024年4月4日 · Cancer cells often develop genetic mutations that initiate and sustain the growth of tumors. The most frequently mutated of these oncogenic driver genes, called KRAS, is associated with some of the most fatal cancer types: lung, pancreatic and colorectal cancers.
Targeting KRAS in cancer - Nature
网页2024年4月18日 · KRAS is a small membrane-bound GTP hydrolase protein that cycles between ‘on’ (GTP-loaded) and ‘off’ (GDP-unloaded) states. This cycling between the ‘on’ and ‘off’ state depends on the...
KRAS gene - MedlinePlus
网页The KRAS gene provides instructions for making a protein called K-Ras that is part of a signaling pathway known as the RAS/MAPK pathway. Learn about this gene and related health conditions.
Sotorasib is First KRAS Inhibitor Approved by FDA - NCI
网页2021年6月25日 · The CodeBreaK 100 trial, funded by Amgen and NCI, is testing sotorasib (previously called AMG510) as a treatment for people with solid tumors that have KRAS G12C. The mutation, a hallmark of damage from cigarette smoke, is …
The current understanding of KRAS protein structure and dynamics
网页2019年12月26日 · GTPase KRas (KRAS) is a signal transducer protein, which plays an important role in various cellular signalling events such as in regulation of cell proliferation.
KRAS and Lung Cancer - American Lung Association
网页2024年6月27日 · The KRAS mutation is an error in a protein in normal cells. It is called KRAS because it was first identified as causing cancer in Kirsten RAt Sarcoma virus. Normally KRAS serves as an information hub for signals in the cell that lead to cell growth.
From bench to bedside: current development and emerging trend of KRAS ...
网页2023年12月4日 · Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most notorious oncogene, which is frequently mutated in various cancers, mainly lung cancer, colorectal cancer, and pancreatic...
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