Nature背靠背 | 组蛋白H1调控染色质结构 - 知乎 - 知乎专栏
网页Arthur I. Skoultchi 教授的研究题为 “H1 histones control the epigenetic landscape by local chromatin compaction”， 该研究发现组蛋白H1通过调控染色质结构来影响表观遗传修饰H3K27me3和H3K36me2的丰度，从而影响基因表达的机制。. 人类细胞中至少有10种不同的组蛋白H1异构体，其中H1A ...
The H1 linker histones: multifunctional proteins beyond the …
网页2015年10月16日 · The linker histone H1 binds to the entry/exit sites of DNA on the surface of the nucleosomal core particle and completes the nucleosome. It influences the nucleosomal repeat length (NRL) 2 and is required to stabilize higher-order chromatin structures such as the so-called 30-nm fibre 3.
H1 histones control the epigenetic landscape by local ... - Nature
网页2020年12月9日 · H1 linker histones are the most abundant chromatin-binding proteins 1. In vitro studies indicate that their association with chromatin determines nucleosome spacing and enables arrays...
Emerging roles of linker histones in regulating chromatin ... - Nature
网页2017年10月11日 · Together with core histones, which make up the nucleosome, the linker histone (H1) is one of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to the...
Histone H1 binding to nucleosome arrays depends on linker …
网页2022年5月17日 · Full-length human linker histone H1.4 (UniProt ID P10412) was codon-optimized for Escherichia coli and synthesized by IDT as a gBlock. The DNA sequence for the GyrA intein was as described 58 and...
组蛋白H1 变体 - 知乎 - 知乎专栏
网页2020年12月7日 · 四个核心组蛋白抱团并被DNA缠绕成为nucleosome，linker组蛋白H1则结合在缠绕核心组蛋白的DNA出口处，从而缝合了nucleosome。 而H1存在着许多的变体，在人和小鼠中共发现了11个变体，其中包括7个体细胞亚型H1.0， H1.1到H1.5以及H1LS1，还有一个oocyte（卵母细胞）特异的亚 ...
Linker histone H1 drives heterochromatin condensation via phase ...
网页2024年2月3日 · Frequently enriched in heterochromatic regions, linker histone H1 is a key chromatin structural protein that binds to entry and exit sites of DNA on the surface of nucleosome core particles to stabilize nucleosome structure and condense chromatin (Hergeth and Schneider 2015).
Angewandte Chemie - Wiley Online Library
网页4 天之前 · Using this strategy, we successfully prepared monoubiquitylated and K63-linked di- and tri-ubiquitylated linker histone H1.0 proteins, which were incorporated into individual chromatosomes. Quantitative biochemical analysis of different RNF168 constructs on ubiquitylated chromatosomes with different ubiquitin chain lengths demonstrated that K63 ...
Role of H1 Linker Histones in Mammalian Development and Stem …
网页H1 linker histones are key chromatin architectural proteins facilitating the formation of higher order chromatin structures. The H1 family constitutes the most heterogeneous group of histone proteins, with eleven non-allelic H1 variants in mammals.
Histone H1.0 couples cellular mechanical behaviors to chromatin ...
网页2024年4月10日 · Histone H1.0 is enriched in fibroblasts and stress responsive. To investigate the role of linker histone isoforms in response to cellular stress, we examined single-cell RNA sequencing...