CTHRC1 promotes liver metastasis by reshaping infiltrated macrophages ...
网页2021年5月13日 · A In vivo imaging analysis of tumor progression in a liver metastatic mouse model by intrasplenic injection of Lenti-vector or Lenti-Cthrc1 MC38 and CT26 cells
Cell cycle-related kinase reprograms the liver immune ... - Nature
网页2020年9月2日 · Using an inducible liver-specific transgenic model, we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer (CRC) metastasis to the liver, which...
Reprogramming the tumor immune microenvironment using
网页2024年8月6日 · C57BL/6 mice were implanted with MC38 cells simultaneously via the subcutaneous (s.c) and intrasplenic routes (SC + liver tumors) (day 0), and sequentially intravenously (i.v) injected with...
Continuous sensing of IFNα by hepatic endothelial cells shapes a ...
网页2022年10月25日 · Treatment with NaCl (red frame) and IFNα (blue frame) was initiated 7 days before MC38 cells intrasplenic injection. Red dashed lines highlight CRC liver metastases, characterized as hypointense and slightly-hyperintense regions in T1- and T2-weighted sequences, respectively.
IL-10 dampens antitumor immunity and promotes liver metastasis …
网页We first induced liver metastasis using an intrasplenic injection of MC38 cells in myeloid cell-specific IL-10Ra-deficient mice and littermate controls. From these mice we then isolated CD8+ T cells from liver metastases, and cocultured them with MC38 cancer cells.
The liver metastatic niche: modelling the extracellular matrix in ...
网页2021年4月15日 · Ma et al. used an intrasplenic prostate cancer cell injection model to show that hepatocytes drive mesenchymal-to-epithelial transition in cancer cells, characterised by increased E-cadherin and ERK and by reduced p38, which leads to resistance to chemotherapy and increased liver metastasis (Ma et al., 2016; Ma and Wells, 2014).
Frontiers | IL-22BP controls the progression of liver metastasis in ...
网页2023年5月30日 · Methods: We used two different murine in vivo metastasis models using the MC38 and LLC cancer cell lines and studied lung and liver metastasis formation after intracaecal or intrasplenic injection of cancer cells. Furthermore, IL22BP expression was measured in a clinical cohort of CRC patients and correlated with metastatic tumor stages.
IFNα gene/cell therapy curbs colorectal cancer colonization of the ...
网页2016年1月14日 · Note that CT26 and MC38 cell lines were found to be sensitive to the anti‐proliferative effect of recombinant IFNα in vitro (Fig EV1A). To avoid intrasplenic tumor growth, the spleen was removed few minutes post‐injection, thus allowing to define the impact of Tie2‐IFNα approach on the growth of CRC cells that have reached the liver.
Control of hepatic metastasis by macrophage STING signaling …
网页STING ΔMФ and STING FL/FL control mice were intrasplenic injected with MC38. Livers and intrahepatic NPCs were collected on Day 14. Numbers (D) and proportions (E) of F4/80 + macrophages, CD4 +...
Macrophage STING signaling promotes NK cell to suppress …
网页2023年3月16日 · Bone marrow-derived macrophages pretreated with MC38 were co-cultured with splenic NK cells for in vitro studies. Results. Significant activation of STING signaling were detected in adjacent and tumor tissues and intrahepatic macrophages.
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