Activity-dependent interdomain dynamics of matrix metalloprotease-1 …
网页2020年11月26日 · We used matrix metalloprotease-1 (MMP1) as a model system to study the relationship between interdomain dynamics and activity because MMP1 has diverse substrates. Here we focus on fibrin, the...
Physiology and pathophysiology of matrix metalloproteases
网页2010年7月18日 · MMP-1 or collagenase-1 was the first described matrix metalloprotease and has sparked a large volume of research on the physiological and pathological role of MMPs. MMP-1 is a secreted enzyme and contains the hemopexin-like domain necessary for degradation of triple-helical collagens.
Matrix metalloproteinases in arthritis: towards precision medicine
网页2023年5月9日 · MMP-1 (collagenase) and MMP-3 (stromelysin-1) are also detected in synovial fluid and in cartilage tissue 54 and might be involved in local inflammation of cartilage, bone, synovium and...
Structure and Function of Human Matrix Metalloproteinases
网页2020年4月26日 · MMP-1 cleaves pro-MMP-2 and -9 into its active form. MMP-1 expression is increased by inflammatory cytokines (TNF-α and IL-1). 8: Collagenase-2; Neutrophil collagenase: Collagen type I, II and III, fibronectin, aggrecan and ovostatin. Cells: chondrocytes, endothelial cells, activated macrophages and smooth muscle cells.
MMP-1 overexpression selectively alters inhibition in D1 spiny ...
网页2018年11月1日 · Matrix metalloproteinase-1 (MMP-1) is a member of the MMP family of secreted, cell surface, zinc dependent endopeptidases 1. While MMP-1 can process extracellular...
MMP-1: the elder of the family - PubMed
网页Human fibroblast collagenase (MMP-1) was the first vertebrate collagenase purified as a protein and cloned as a cDNA, and is considered the prototype for all the interstitial collagenases. It is synthesized as a zymogen where N-terminal residues are removed by proteolysis and shares with other MMPs a catalytic domain and a carboxy terminal ...
Matrix Metalloproteinases Inhibitors in Cancer Treatment: An …
网页2023年7月21日 · Recent studies suggest that MMP-1 promotes cancer cell invasion and migration and significantly correlates with malignancies’ unfavorable outcomes [45, 46]. Increased MMP-1 expression has been observed in oral, bladder, gastric, and breast cancers and was linked to a poor prognosis for these diseases [47, 48, 49, 50].
Matrix metalloproteinase 1 (MMP1) is associated with early
网页Matrix metalloproteinases (MMP) play a key role in the breakdown of extracellular matrix and in inflammatory processes. MMP1 is the most highly expressed interstitial collagenase degrading fibrillar collagens. Overexpression of MMP1 has been shown in tumor tissues and has been suggested to be associ ….
The role of matrix metalloproteinases in aging: Tissue remodeling …
网页2017年11月1日 · Matrix metalloproteinases (MMPs) are one of the most important families of proteases involved in the tight control of ECM remodeling over time. In this review, we will discuss how MMPs and other proteases alter ECM composition and mechanical properties in aging, thereby affecting stem cell niches and the development of senescent phenotypes.
Interstitial Collagenase - an overview | ScienceDirect Topics
网页Collagenases including MMP-1, MMP-8, MMP-13 and MMP-18 (identified in Xenopus) are essential for cleavage of several types of interstitial collagens (collagen type I, II and III) at the particular site to form 3/4 and 1/4 fragments [19, 20]. They can also cleave ECM molecule and non-ECM molecules.