Mannan-Binding Lectin Pathway Function Test (C4b) - Quest …
网页Mannan-Binding Lectin Pathway Function Test (C4b) - Deficiency in either MBL or MASP-2 appears to predispose individuals to serious infections (e.g. pneumonitis, sepsis, osteomyelitis, gastroenteritis and meningitis) especially during childhood before the adaptive immunity has fully developed.
004900: Mannose-binding Lectin (MBL) - Labcorp
网页Enzyme-linked immunosorbent assay (ELISA) using microwells coated with the unique monoclonal antibody to capture MBL via an epitope near its carbohydrate-binding site. Bound MBL is detected with the same antibody that has been labeled with biotin.
Mannan-binding lectin - Wikipedia
网页One way the most-recently discovered lectin pathway is activated is through mannose-binding lectin protein. MBL binds to carbohydrates (to be specific, D-mannose and L-fucose residues) found on the surfaces of many pathogens. For example, MBL has been shown to bind to: yeasts such as Candida albicans [19] [20] viruses such as HIV [21] and ...
MBLF - Overview: Mannan Binding Lectin Complement Pathway, …
网页The Wieslab enzyme-linked immunosorbent assay complement assay for the mannan-binding lectin (MBL) pathway combines principles of the hemolytic assay for complement activation with the use of labeled antibodies specific for neoantigens produced as a result of complement activation.
Mannose-binding lectin deficiency - MedlinePlus
网页Mannose-binding lectin deficiency is a condition that affects the immune system. People with this condition have low levels (deficiency) of an immune system protein called mannose-binding lectin in their blood. Whether this deficiency makes affected individuals prone to recurrent infections is not clear.
Targeting Mannose-Binding Lectin Confers Long-Lasting …
网页2012年8月9日 · This study documents the pivotal role of mannose-binding lectin (MBL), a circulating protein that acts as the first step in activation of the lectin complement pathway in brain ischemic injury. The data show that MBL deposition on the ischemic endothelium represents a key pathogenetic event in brain damage.
Mannose-Binding Lectin: Biologic Characteristics and Role in the ...
网页2017年1月26日 · The mannose-binding lectin (MBL) is a protein of the innate immune system, belonging to the collectin family, able to deploy a variety of antimicrobial activities. It recognizes and binds various pathogens (including bacteria, viruses, fungi, and parasites), providing protection against the microbial invasion of the host [ 1 ].
The mannose-binding lectin: a prototypic pattern recognition …
网页2005年12月20日 · The mannose-binding lectin (MBL) is an evolutionary conserved circulating host defense protein that acts as a broad-spectrum recognition molecule against a wide variety of infectious agents. Target binding triggers the MBL pathway of …
Mannose-Binding Lectin in Human Health and Disease
网页2021年3月13日 · Mannose-binding lectin (MBL) plays, as a soluble pattern recognition molecule, a central role in the innate immune response. MBL binds to the surface of carbohydrates on a wide variety of pathogens and mediates opsonophagocytosis via activation of the lectin...
The ambiguous role of mannose-binding lectin (MBL) in human …
网页2021年2月17日 · Mannose-binding lectin (MBL) and lectin complement pathway have become targets of increasing clinical interest. Many aspects of MBL have been recently explored, including the structural properties that allow it to distinguish self from non-self/altered-self structures.