004900: Mannose-binding Lectin (MBL) - Labcorp
网页Enzyme-linked immunosorbent assay (ELISA) using microwells coated with the unique monoclonal antibody to capture MBL via an epitope near its carbohydrate-binding site. Bound MBL is detected with the same antibody that has been labeled with biotin.
Mannose Binding Lectin | ARUP Laboratories Test Directory
网页Mannose-binding protein is a component of the innate or natural immune system which binds to mannose residues on a variety of different microorganisms. When bound, this lectin will trigger the complement pathway resulting in opsonization. Mannose-binding protein is also an acute phase reactant produced by the liver.
MBLF - Overview: Mannan Binding Lectin Complement Pathway, …
网页The Wieslab enzyme-linked immunosorbent assay complement assay for the mannan-binding lectin (MBL) pathway combines principles of the hemolytic assay for complement activation with the use of labeled antibodies specific for neoantigens produced as a result of complement activation.
Mannan-Binding Lectin Pathway Function Test (C4b)
网页Mannan-Binding Lectin Pathway Function Test (C4b) - Deficiency in either MBL or MASP-2 appears to predispose individuals to serious infections (e.g. pneumonitis, sepsis, osteomyelitis, gastroenteritis and meningitis) especially during childhood before the adaptive immunity has fully developed.
Mannose-binding lectin deficiency - MedlinePlus
网页Relatively common mutations in the MBL2 gene can lead to mannose-binding lectin deficiency. This gene provides instructions for making a protein that assembles into a complex called mannose-binding lectin.
The mannose-binding lectin: a prototypic pattern recognition …
网页2005年12月20日 · The mannose-binding lectin (MBL) is an evolutionary conserved circulating host defense protein that acts as a broad-spectrum recognition molecule against a wide variety of infectious agents. Target binding triggers the MBL pathway of …
The Lectin Pathway of the Complement System—Activation, …
网页2024年1月26日 · Mannose-binding lectin (MBL), other collectins, and ficolins are collectively termed as the pattern recognition molecules (PRMs) of the LP, and they are responsible for targeting LP activation to molecular patterns, e.g., on bacteria.
网页Mannose-binding lectin (MBL) deficiency is a condition that affects the immune system. It is a fairly common condition, affecting approximately 5–30 people in every 100. People with this condition have low levels of an immune system protein called mannose-binding lectin in …
Targeting Mannose-Binding Lectin Confers Long-Lasting …
网页2012年8月9日 · This study documents the pivotal role of mannose-binding lectin (MBL), a circulating protein that acts as the first step in activation of the lectin complement pathway in brain ischemic injury. The data show that MBL deposition on the ischemic endothelium represents a key pathogenetic event in brain damage.
Mannose Binding Lectin | Cleveland Clinic Laboratories
网页This test is useful for initial screening for suspected deficiency in the lectin complement pathway. Mannose-binding protein is a component of the innate or natural immune system which binds to mannose residues on a variety of different microorganisms. When bound, this lectin will trigger the complement pathway resulting in opsonization.
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