The ocular adverse effects of oral drugs - PMC - National Center …
网页2021年8月2日 · As well as retinal toxicity, oral drugs can affect other parts of the eye including the cornea, lens and optic nerve. Consider drugs as a possible cause of unexplained ocular symptoms. Communication between the prescribing clinician and ophthalmologist will facilitate the best possible patient care.
Drug Toxicity to the Retina and Optic Nerve: Are You Missing It?
网页2019年9月1日 · Several systemic drugs, including hydroxychloroquine, ethambutol, pentosan, thioridazine, and various cancer drugs, are known to cause toxicity to the posterior segment of the eye. Keeping them in mind can help preserve a patient’s vision.
Ocular toxicities associated with targeted anticancer agents: …
网页2017年8月8日 · Ocular toxicities are among the most common adverse events resulting from targeted anticancer agents and are becoming increasingly relevant in the management of patients on these agents.
Adverse Ocular Effects of Systemic Medications - PMC
网页2023年2月28日 · While ocular complications of systemic medications are uncommon, it is important to recognize that vision-threatening toxicities can occur. This review details the vision-threatening adverse effects of a select group of commonly prescribed systemic medications and describes the recommended screening guidelines for …
Systemic Drugs and Ocular Toxicity: A Review - Review of …
网页2022年11月10日 · The table on the following page summarizes the recently approved medications and a few other commonly used pediatric medications with ocular toxicities. Following are the medications and their toxicity issues to be aware of.
Ocular toxicities associated with antibody drug conjugates and
网页On-and off-target ocular toxicities are prevalent treatment-related adverse events of newer therapies including antibody drug conjugates (ADCs) and immunotherapy. Ocular toxicities associated with ADCs and immunotherapy have heterogeneous presentations and pathogenesis requiring unique and often complex monitoring, and management.
Ocular toxicities associated with anticancer therapies: Are we …
网页2022年6月2日 · Results: The most common ocular toxicities were mild including “visual disturbances” and conjunctivitis. Severe toxicities were reported as well, including corneal ulceration, retinal vascular occlusion, optic neuritis, and even cortical blindness.
Systemic Chemotherapy and Ocular Toxicities - EyeWiki
网页. Contents. 1 Introduction. 2 Mitogen Activating Protein Kinase (MAPK) Pathway Inhibitors. 3 Antibody Drug Conjugates. 4 Immune Checkpoint Inhibitors. 5 Epidermal Growth Factor Receptor (EGFR) Inhibitors. 5.1 Corneal and Conjunctival Toxicity: 5.2 Periorbital Toxicity: 5.3 Anterior Uveitis: 6 Human Epidermal Growth Factor 2 (HER2) Inhibitors.
Ocular Toxicity Studies: Pathology Report - SAGE Journals
网页2020年8月20日 · Ocular toxicity studies are the bedrock of nonclinical ocular drug and drug–device development, and there has been an evolution in experience, technologies, and challenges to address that ensures safe clinical trials and marketing authorization.
Antibody-Drug Conjugates and Ocular Toxicity - PubMed
网页2023年8月23日 · Some of the most common toxicities include microcyst-like epithelial keratopathy and dry eye. We discuss proposed mechanisms of ocular toxicity and describe the reports that mention these toxicities. We focus on ADCs with the most published literature and the most significant effects on ocular tissue.