Carbadox and Olaquindox as Feed Additives (updated 13 Apr.) - The Pig Site
网页2001年4月13日 · For carbadox and olaquindox the pig is the only approved target species. For both, use is permitted up to 50 mg/kg of complete feedingstuff for pigs up to 4 months of age and a 4 week minimum withdrawal period is required.
Tissue Depletion of Olaquindox and Its Six Metabolites in Pigs …
网页2021年4月23日 · The results that deoxyolaquindox occurs at higher concentrations in kidney tissue and is more persistent than other residues in edible tissues of pigs which indicate that deoxyolaquindox is the most relevant marker residue and should be monitored in the routine surveillance of olaquindox-related residues in foods of animal origin.
Tissue Depletion of Olaquindox and Its Six Metabolites in Pigs …
网页2021年4月22日 · Olaquindox (OLQ) has been used as antimicrobial growth promotants (AGPs) for decades to improve feed efficiency and control pig dysentery and bacterial enteritis in young pig. Metabolism studies in rats, chickens, and pigs illustrated that OLQ rapidly converted into monooxy and deoxy metabolites in vivo , which could be further biotransformed ...
The metabolism of olaquindox in rats, chickens and pigs
网页2011年1月15日 · To provide the interpretation of toxicities in animals, this study explored the metabolism of olaquindox in rats, chickens and pigs of different genders by qualitative metabolite profiling. Animals were fed olaquindox in an oral dose, and then their urine, plasma, feces, liver, kidney and muscle were collected.
Olaquindox as performance-promoting feed additive for growing pigs
网页1979年9月1日 · Olaquindox (trade name: Bay-o-nox, Bayer Co.) is a quinoxalin derivative (C 12 H 13 N 3 O 4). Its efficacy was tested with particular reference to diets with and without a copper supplement. Olaquindox was included in the diet of pigs up to 54 kg liveweight, but performance was monitored between 18 and 87 kg. The daily gain and feed: gain ratio ...
Discovery of the Marker Residue of Olaquindox in Pigs ... - PubMed
网页2019年6月12日 · The excretion, metabolism, distribution, and residue depletion of olaquindox (OLA), an antibacterial and growth-promoting agent used in food-producing animals for decades without a clear understanding of metabolic fate, was completely studied in pigs, broilers, carp, and rats using a radio-tracing a ….
The metabolism of olaquindox in rats, chickens and pigs
网页2011年1月15日 · In this study, comparative metabolism of olaquindox was investigated in rats, chickens and pigs with different genders. It was shown that olaquindox undergoes extensive metabolism, with 18, 18 and 16 metabolites of rats, chickens and pigs being excreted, respectively.
Discovery of the Marker Residue of Olaquindox in Pigs, …
网页2019年5月16日 · Olaquindox is used in China as feed additive for growth promotion in pigs. Recently, we have demonstrated that olaquindox induced genome DNA damage and oxidative stress in HepG2 cells.
Tissue Depletion of Olaquindox and Its Six Metabolites in Pigs …
网页2021年4月1日 · The results that deoxyolaquindox occurs at higher concentrations in kidney tissue and is more persistent than other residues in edible tissues of pigs which indicate that deoxyolaquindox is the...
Journal of Veterinary Pharmacology and Therapeutics
网页2013年4月30日 · To estimate the consumer exposure to olaquindox (OLA) residues in porcine edible tissues, a physiologically based pharmacokinetic (PBPK) model for methyl-3-quinoxaline-2-carboxylic acid (MQCA), the marker residue of OLA, was developed in pigs based on the assumptions of the flow-limited distribution, hepatic …