Interpretation of P53 Immunohistochemistry in Endometrial …
网页2018年12月14日 · Mutation-type p53 immunostaining serves as an indicator of the Cancer Genome Atlas (TCGA)-based molecular subtype of endometrioid carcinoma with the worst prognosis, especially when applied as part of a diagnostic algorithm 1,2.
p53 immunohistochemistry in endometrial cancer: clinical and …
网页2022年6月25日 · These discordant cases illustrate the importance of a quality-assured p53 immunostaining procedure, good internal controls, optimal pre-processing of tumor tissue and awareness of all the ...
p53 immunostaining pattern is a useful surrogate marker for
网页2022年12月5日 · Through annotation of TP53 mutations according to the predicted effects on p53 protein function and classification of p53 IHC patterns according to the presence of overexpression or complete loss of expression, we investigated the association between the TP53 mutation status and p53 IHC pattern.
Clinical outcomes of immunohistochemistry of the p53 Staining …
网页2022年7月29日 · In our study, the mutation pattern of p53 immunostaining was found in 93.54% of cases when cutoff values of >60% for overexpression and 0% for lack of expression were used. The diagnosis of HGSOC was based on histologic morphology according to the 2014 WHO classification.
p53 Immunohistochemical patterns in HPV-related neoplasms …
网页2020年4月1日 · HPV ISH revealed an inverse relationship with p53, cells positive for HPV mRNA were negative for p53. Knowledge of these patterns can help pathologists avoid misinterpreting p53 status in the...
Interpretation of P53 Immunohistochemistry in Endometrial …
网页P53 immunohistochemistry has evolved into an accurate surrogate reflecting the underlying TP53 mutation status of a tumor, and has utility in the diagnostic workup of endometrial carcinomas. Recent work predominantly carried out in tubo-ovarian high-grade serous carcinoma has revealed 4 main pattern ….
Significance of p53 immunostaining in mesothelial proliferations and ...
网页2021年9月8日 · p53 immunohistochemistry has long been proposed for the separation of benign from malignant mesothelial proliferations, with the older literature suggesting that any degree of positivity...
p53abn Endometrial Cancer: understanding the most aggressive ...
网页2021年2月15日 · Immunostaining for p53 stratifies the remaining endometrial cancers into those with wild-type staining pattern and those with mutant pattern staining (p53abn endometrial cancer). This latter group of p53abn endometrial cancer …
p53 immunohistochemistry in endometrial cancer: clinical and …
网页P53abn EC are POLE wildtype, mismatch repair proficient and show abnormal immunohistochemical (IHC) staining for p53. Correct interpretation of routinely performed p53 IHC has therefore become of paramount importance. We aimed to comprehensively investigate abnormal p53 IHC patterns and their relation …
Subclonal p53 immunostaining in the diagnosis of endometrial …
网页In endometrial carcinoma, subclonal p53 immunostaining outside the context of mismatch repair-deficient and POLE-mutated subtype, where it does not impact molecular subtype diagnosis, is rare and the current cut-off of ≥10% mutant pattern staining to diagnose p53 abnormal EC serves to identify those patients with more aggressive disease.
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