Contribution of p53 in sensitivity to EGFR tyrosine kinase
网页2021年10月4日 · To evaluate the effects of p53 in primary sensitivity and acquired resistance to EGFR-TKIs in NSCLC cells with activating EGFR mutations, we generated p53 knockout cells, including PC-9...
Domain-specific p53 mutants activate EGFR by distinct ... - Nature
网页2023年3月28日 · We report here that p53 DNA-binding domain (DBD) and transactivation domain (TAD) mis-sense mutants unexpectedly activate pro-carcinogenic epidermal growth factor receptor (EGFR) signaling via...
EGFR suppresses p53 function by promoting p53 binding to DNA …
网页2022年10月3日 · Results: Using glioma sphere-forming cells (GSCs), we identified, DNA-PKcs as a p53 interacting protein that functionally inhibits p53 activity. We demonstrate that EGFR knockdown increased wt-p53 transcriptional activity, which was associated with decreased binding between p53 and DNA-PKcs.
Domain-specific p53 mutants activate EGFR by distinct …
网页2023年3月28日 · We report here that p53 DNA-binding domain (DBD) and transactivation domain (TAD) mis-sense mutants unexpectedly activate pro-carcinogenic epidermal growth factor receptor (EGFR) signaling via distinct, …
Contribution of p53 in sensitivity to EGFR tyrosine kinase …
网页2021年10月4日 · We investigated the role of p53 in NSCLC cells harboring mutant EGFR using p53 overexpression or knockout to determine sensitivity to EGFR-TKIs. We analyzed whether the loss of p53 or mutant p53 affects the sensitivity or …
Domain-specific p53 mutants activate EGFR by distinct …
网页2023年3月28日 · Our findings suggest that p53 mutants carrying gain-of-function, mis-sense mutations affecting two different domains form new protein complexes that promote carcinogenesis by enhancing EGFR signaling via distinctive mechanisms, exposing clinically relevant therapeutic vulnerabilities.
Contribution of p53 in sensitivity to EGFR tyrosine kinase ... - PubMed
网页2021年10月4日 · The emergence of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) with activating EGFR mutations is a major hindrance to treatment. We investigated the effects of p53 in primary sensitivity and acquired resistance to EGFR-T …
DNA damage alters EGFR signaling and reprograms cellular
网页2022年4月6日 · RNAseq and functional analysis reveal that DNA damage induces a shift in cell response to EGFR triggering that potentiates DDR-induced p53 pathway and cell cycle arrest.
TP53 Co-Mutations in Advanced EGFR-Mutated Non–Small Cell …
网页2022年4月4日 · High PD-L1 expression was significantly associated with EGFR co-mutation with tumor suppressor genes such as TP53, while EGFR mutation alone was not associated with high PD-L1 expression, and these results might explain why advanced NSCLC patients with EGFR mutation alone showed poor response to immunotherapy and patients with EGFR/TP53 co ...
EGFR suppresses p53 function by promoting p53 binding to DNA …
网页2022年4月26日 · To determine how EGFR regulates p53 activity and to identify binding partners of p53 that are EGFR dependent, we performed a p53 immunoprecipitation experiments followed by coomassie blue staining of samples from EGFR deleted mut-p53 and control cells.