Penicillin-Binding Protein 2a of Methicillin-Resistant
网页High-level resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is due to expression of penicillin-binding protein 2a (PBP2a), a transpeptidase that catalyzes cell-wall crosslinking in the face of …
Penicillin binding protein 2a: An overview and a medicinal chemistry ...
网页2020年8月1日 · An Achilles' heel of MRSA, PBP2a represents a substantial target to design novel antibiotics to tackle MRSA threat via inhibition of the bacterial cell wall biosynthesis. In this review we bring into focus the PBP2a enzyme and examine the various aspects related to its role in conferring resistance to MRSA strains.
Penicillin‐binding protein PBP2a provides variable levels of …
网页2020年5月17日 · Methicillin‐resistant Staphylococcus aureus (MRSA) is resistant to most β‐lactams due to the expression of an extra penicillin‐binding protein, PBP2a, with low β‐lactam affinity.
Penicillin-binding protein PBP2a provides variable levels of …
网页2020年5月20日 · Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to most β-lactams due to the expression of an extra penicillin-binding protein, PBP2a, with low β-lactam affinity. It has long been known that heterologous expression of the PBP2a-encoding mecA gene in methicillin-sensitive S. aureus (M ….
Thermosensitive PBP2a requires extracellular folding factors …
网页2019年11月15日 · Methicillin resistant Staphylococcus aureus (MRSA) is particularly problematic and originates by the horizontal acquisition of mecA encoding PBP2a, an...
Inhibition of penicillin-binding protein 2a (PBP2a) in methicillin ...
网页2015年6月10日 · The expression of PBP2a in MRSA in treatment of 1/64 × MIC ampicillin + 1/4 × MIC F-10 was studied. The controls include untreated MRSA, untreated MSSA and MRSA grown in only one test sample (ampicillin or F-10) at sub-inhibitory concentrations that were same as in the combination treatment.
Structural basis for the β lactam resistance of PBP2a from ... - Nature
网页2002年10月21日 · The key determinant of the broad-spectrum β-lactam resistance in MRSA strains is the penicillin-binding protein 2a (PBP2a). Because of its low affinity for β-lactams, PBP2a provides transpeptidase...
Rapid MRSA detection via tandem mass spectrometry of the
网页2021年9月15日 · Identification of methicillin-resistant Staphylococcus aureus (MRSA) is often accomplished through the detection of penicillin-binding protein 2a (PBP2a). With greater...
Penicillin-binding protein 2a of methicillin-resistant ... - PubMed
网页High-level resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is due to expression of penicillin-binding protein 2a (PBP2a), a transpeptidase that catalyzes cell-wall crosslinking in the face of …
Penicillin binding protein 2a: An overview and a medicinal …
网页2020年8月1日 · An Achilles’ heel of MRSA, PBP2a represents a substantial target to design novel antibiotics to tackle MRSA threat via inhibition of the bacterial cell wall biosynthesis. In this review we bring into focus the PBP2a enzyme and examine the various aspects related to its role in conferring resistance to MRSA strains.