PLGA-based nanoparticles: An overview of biomedical …
网页2012年7月20日 · PLGA nanoparticles are described in the literature as effective nanocarriers for the encapsulation of various anti-cancer agents such as paclitaxel [19], 9-nitrocamptothecin [20], cisplatin [21], etc. but also for the encapsulation of various drugs such as haloperidol [22], estradiol [23], etc.
PLGA-based nanoparticles: an overview of biomedical applications
网页2012年7月20日 · This review presents why PLGA has been chosen to design nanoparticles as drug delivery systems in various biomedical applications such as vaccination, cancer, inflammation and other diseases.
PLGA-Based Micro/Nanoparticles: An Overview of Their …
网页2023年2月22日 · Poly (lactic-co-glycolic acid) micro/nanoparticles (PLGA M/NPs) have good biocompatibility, biodegradability and unique physical and chemical properties, making them one of the most popular and effective drug delivery polymers.
PLGA-Based Nanoparticles in Cancer Treatment - PMC
网页2018年11月2日 · This review article gives an overview of the properties of previously reported PLGA nanoparticles (NPs), their behavior in biological systems, and their use for cancer therapy. Strategies are emphasized to target PLGA NPs to …
Drug-loaded PEG-PLGA nanoparticles for cancer treatment
网页2022年8月19日 · Nanoparticles based on single-component synthetic polymers, such as poly (lactic acid-co-glycolic acid) (PLGA), have been extensively studied for antitumor drug delivery and adjuvant therapy due to their ability to encapsulate and release drugs, as well as passively target tumors.
pH-responsive high stability polymeric nanoparticles for targeted ...
网页2020年3月3日 · The NPs consist of a drug-loaded polylactic-co-glycolic acid (PLGA) core covalently ‘wrapped’ with a crosslinked bovine serum albumin (BSA) shell designed to minimize interactions with...
PLGA-based nanoparticles: A new paradigm in biomedical …
网页2016年6月1日 · The present review describes in detail the characteristics of PLGA and its associated potentials in terms of the structure–property relationship. The efficacy of PLGA nanoparticles was improved through ligand anchoring, which were applied as mediators for gene delivery, in imaging of cancer and in the field of theranostics. 2.
Controlled release and targeted drug delivery with poly(lactic-co ...
网页2022年7月9日 · Poly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs) hold tremendous promise for such applications because of their ability to modulate drug release, pharmacokinetics, the biodistribution profiles of drugs, and the surface functionalization for targeted delivery.
PLGA-based nanoparticles: An overview of biomedical applications
网页2012年7月20日 · Treatment of cerebral diseases with PLGA-based nanoparticles. The blood–brain barrier (BBB) limits the delivery of drugs to the brain. Endothelial cells of BBB linked to themselves by tight junctions filter the passage of most of the compounds from the bloodstream to the brain parenchyma.
PLGA-Based Nanoparticles for Neuroprotective Drug Delivery …
网页2021年7月8日 · This review will present an overview of the latest findings and advances in the PLGA NP-based approach for neuroprotective drug delivery in the case of neurodegenerative disease treatment (i.e., Alzheimer's, Parkinson's, Huntington's diseases, Amyotrophic Lateral, and Multiple Sclerosis).