The prospective of liquid crystals in nano formulations for drug ...
网页2021年12月5日 · Cubic and hexagonal liquid crystal gels have been developed for ocular delivery of pilocarpine nitrate on anti-glaucoma treatment, showing that liquid crystal gels could maintain effective concentration of pilocarpine nitrate in aqueous humor for 12 hrs period, with improved bioavailability and also significant lowering the intraocular pressure ...
A practical and scaleable total synthesis of the jaborandi alkaloid ...
网页2009年9月26日 · Subsequent hydrogenation of the α-ethylidene lactone introduces the C(3)-stereochemistry to give a 72:28 mixture of (+)-pilocarpine and (+)-isopilocarpine, which are readily separable via recrystallisation of the (+)-pilocarpine nitrate salt.
Cubic and hexagonal liquid crystal gels for ocular delivery with ...
网页The objective of this work was to investigate phytantriol-based liquid crystal (LC) gels including cubic (Q 2 ) and hexagonal (H 2 ) phase for ocular delivery of pilocarpine nitrate (PN) to treat glaucoma. The gels were produced by a vortex method and confirmed by crossed polarized …
Self-assembled hexagonal liquid crystalline gels as novel ocular ...
网页2019年5月1日 · The aim of this paper was to develop hexagonal liquid crystalline (H II) gels that can be used as a novel ocular delivery system for pilocarpine nitrate (PN). H II gels were prepared by a vortex method using phytantriol/triglyceride/water (71.15: …
Pilocarpine - ScienceDirect
网页1983年1月1日 · Pilocarpine possesses several pharmacological properties—it possesses a miotic action and lowers the intraoccular pressure. Its chief clinical application in ophthalmology has been for the treatment of glucoma in buffered isotonic solution ranging from 0.5–6% as pilocarpine nitrate or hydrochloride.
A Novel Phytantriol-Based Lyotropic Liquid Crystalline Gel for ...
网页2019年1月2日 · The purpose of this paper was to investigate the potential of liquid crystalline (LC) gels for ophthalmic delivery, so as to enhance the bioavailability of pilocarpine nitrate (PN). The gels were prepared by a vortex method …
(PDF) In Situ Liquid Crystal Gel as a New Ophthalmic Drug …
网页2021年6月21日 · The purpose of this article is to develop an in-situ liquid crystal gel that can be used as a novel ocular delivery system for pilocarpine nitrate (PN). The phytantriol (PT) -based in situ...
A Novel Phytantriol-Based Lyotropic Liquid Crystalline Gel for ...
网页2019年1月2日 · Jie Huang, Chunling Tian, Mengqiu Xia, Liu Liu, Zhengguang Li, Jiaojiao Cao, Shuangying Gui & Xiaoqin Chu. Abstract. The purpose of this paper was to investigate the potential of liquid crystalline (LC) gels for ophthalmic delivery, so as to enhance the bioavailability of pilocarpine nitrate (PN).
(PDF) 31- Analytical Profile of Pilocarpine. - ResearchGate
网页1983年1月1日 · Pilocarpine can be identified (4a) by forming cha- racteristic crystals, with the following reagents: a) Gold bromide solution; feathering rosettes
Teaching an Old Drug New Tricks: Agonism, Antagonism, and …
网页2017年6月14日 · Pilocarpine is a prototypical drug used to treat glaucoma and dry mouth and is classified as either a full or partial muscarinic agonist. Here, we report several unexpected results pertaining to its interaction with muscarinic M3 receptor (M3R).