Effects of topical pilocarpine on ocular growth and refractive ...
网页Purpose: This study aimed to investigate whether topical pilocarpine affects ocular growth and refractive development as well as the underlying biochemical processes in early eye development in rabbits. Methods: Twenty three-week-old New Zealand white rabbits were treated with 0.5% pilocarpine in the right eye for 6 weeks. The left eyes served ...
Effects of topical pilocarpine on ocular growth and refractive ...
网页2020年6月11日 — This study aimed to investigate whether topical pilocarpine affects ocular growth and refractive development as well as the underlying biochemical processes in early eye development in rabbits. Methods:
Effect of ocular pigmentation on pilocarpine pharmacology in the rabbit …
网页1984年3月1日 — In this study we have compared the time course of miosis after ocular application of various pilocarpine doses in albino and pigmented rabbit eyes. The drug was administered in aqueous eye drops and polymer matrices. The latter dosage form is intended to prolong the duration of the drug action in the eye.
Full article: Formulation and investigation of pilocarpine ...
网页2020年6月18日 — It is a nonselective muscarinic receptor agonist which acts therapeutically at the muscarinic acetylcholine receptor M 3, found on the iris sphincter muscle, causing the muscle to contract resulting in pupil constriction (miosis). Pilocarpine hydrochloride also acts on the ciliary muscle and causes it to contract.
Adrenergic and cholinergic drug effects of rabbit eyes after ...
网页1978年2月1日 — Effect of topically applied pilocarpine (A) and carbachol (B) on pupil size of denervated and control rabbit eyes. Each value represents the mean -+ S.E.M. for 5 animals. ganglion, pupil size of the experimental eyes prior to drug administration was found to be significantly reduced (5.0 -+ 0.14 mm; p < 0.001).
Effects of topical pilocarpine on ocular growth and refractive ...
网页2020年6月11日 — The effects of pilocarpine on refractive error, corneal curvature and ocular biometrics were assessed using streak retinoscopy, keratometry, and A-scan ultrasonography, respectively. Eyeballs...
Effect of ocular pigmentation on pilocarpine pharmacology in the rabbit ...
网页1984年1月1日 — Systemic absorption of ocularly applied pilocarpine was rapid. In the eye pilocarpine was efficiently and equally metabolized to pilocarpic acid in albino and pigmented rabbits. Pilocarpine accumulated in the pigmented iris, ciliary body, and choroid and retina more than in the corresponding albino tissues.
histological-study-of-rabbit-lacrimal-glands-under-effect-of ...
网页2021年2月25日 — Eighteen male rabbits were used in this experiment to show the effect of Pilocarpine. Different doses of drugs 3mg/kg and 5mg/kg were given to treated groups (B and C) within the therapeutic...
Comparative effects of pilocarpine in different vehicles on pupil ...
网页Several commercial pilocarpine preparations have been compared for their efficacy of drug delivery as evaluated by changes in pupil diameter, and return to base-line pupil size, in rabbits and squirrel monkeys. Adsorbocarpine, Isoptocarpine, Pilocar, all at 2%, and Pilopine HS gel, 4%, were used.
Effect of Ocular Pigmentation on Ocular Disposition, Metabolism …
网页In albino and pigmented rabbit eyes, the ocular disposition, metabolism and biophasic availability of ocularly applied pilocarpine was studied by radioactive technique, TLC and by registration of pilocarpine-induced miosis.