Mouse PVRIG Has CD8 - National Center for Biotechnology …
网页In this study, we investigated the role of mouse PVRIG in syngeneic tumor models using PVRIG-knockout mice and anti-PVRIG. We demonstrate that PVRIG has a different expression profile on murine T-cell subsets compared with TIGIT and that its dominant ligand, PVRL2, is upregulated on myeloid and tumor cells in …
Abstract 1649: Humanized PVRIG mice: A novel tool for …
网页2022年6月15日 · To explore the translational potential of inhibiting PVRIG, we evaluated the efficacy of PVRIG antibodies by generating a humanized B-hPVRIG mouse model. In this model, the mouse Pvrig gene was replaced by the human counterpart, and expression of the human PVRIG protein was confirmed in homozygous B-hPVRIG mice.
Blockade of checkpoint receptor PVRIG unleashes anti-tumor …
网页2021年6月26日 · Genetic knock-out of PVRIG in mice or treatment with anti-PVRIG mAb (both early and late treatments) significantly inhibited the exhaustion of NK cells and slowed tumor growth in several murine tumor models. We showed that besides CD8 + T cells, the presence of NK cells was also critical for the therapeutic effects of PVRIG blockade ...
Mouse PVRIG Has CD8 + T Cell-Specific Coinhibitory Functions …
网页PVRIG-deficient mouse CD8 + T cells mounted a stronger antigen-specific effector response compared with wild-type CD8 + T cells during acute Listeria monocytogenes infection. Furthermore, enhanced CD8 + T-cell effector function inhibited tumor growth in PVRIG -/- mice compared with wild-type mice and PD-L1 blockade conferred a synergistic ...
Blockade of checkpoint receptor PVRIG unleashes anti-tumor ... - PubMed
网页2021年6月26日 · PVRIG is a recently identified immune checkpoint receptor and blockade of which could reverse T cell exhaustion to treat murine tumor; however, its therapeutic potential via NK cells in mice and human remains seldom reported.
PVRIG is a novel natural killer cell immune checkpoint receptor in ...
网页2021年12月1日 · Poliovirus receptor-related immunoglobulin domain-containing (PVRIG) has recently been identified as an immune checkpoint molecule with potential for therapeutic development. 1 In humans, PVRIG is expressed on T cells (predominantly CD8 + T cells) and natural killer (NK) cells, but not on …
Immune checkpoint molecules in natural killer cells as potential ...
网页2020年10月29日 · CD112R, also known as poliovirus receptor-related immunoglobulin domain protein (PVRIG), is a newly identified inhibitory checkpoint receptor in the PVR-like family.
PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8 - PubMed
网页PVRIG is a coinhibitory receptor of the DNAM/TIGIT/CD96 nectin family that binds to PVRL2. We report that antagonism of PVRIG and TIGIT, but not CD96, increased CD8 + T-cell cytokine production and cytotoxic activity. The inhibitory effect of PVRL2 was mediated by PVRIG and not TIGIT, demonstrating that the PVRIG-PVRL2 pathway is a …
[PDF] Mouse PVRIG Has CD8+ T Cell–Specific ... - Semantic Scholar
网页2019年1月18日 · PVRIG is an inducible checkpoint receptor and that targeting PVRIG–PVRL2 interactions results in increased CD8+ T-cell function and reduced tumor growth, according to the mouse tumor microenvironment. Expression of PVRIG, an immune checkpoint target, is upregulated on activated and tumor-infiltrating CD8+ T cells in mice.
Blockade of checkpoint receptor PVRIG unleashes anti-tumor …
网页2021年6月26日 · By using Rag1−/− mice, we demonstrated that PVRIG blockade could provide therapeutic effect in the absence of adaptive immunity. Further, blockade of human PVRIG with monoclonal antibody enhanced human NK cell function and inhibited human tumor growth in NK cell- or PBMC-reconstituted xenograft mice.
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