CD4-CD8 differentiation in the thymus: connecting circuits and …
网页The proper choice of the CD4-helper or CD8-cytotoxic lineages by developing T cells is crucial for the generation of an antigen-responsive and functionally fit T cell repertoire. Here we present a brief overview of the transcriptional control …
Single-cell multiomic analysis of thymocyte development ... - Nature
网页2023年8月14日 · The development of CD4+ T cells and CD8+ T cells in the thymus is critical to adaptive immunity and is widely studied as a model of lineage commitment.
CD4+/CD8+ double-positive T cells: more than just a ... - PubMed
网页CD4(+)/CD8(+) DP thymocytes are a well-described T cell developmental stage within the thymus. However, once differentiated, the CD4(+) lineage or the CD8(+) lineage is generally considered to be fixed. Nevertheless, mature CD4(+)/CD8(+) DP T cells have been described in the blood and peripheral lym …
Thymus and T Cell Development Focus: The partitioning of TCR ...
网页Initially, CD4 − CD8 − DN thymocytes expressing pre-TCRα (pTα) and TCRβ undergo β-selection; successful thymocytes then progress to expressing the co-receptors CD4 and CD8, becoming DP thymocytes, and initiate TCRα rearrangement. The rearranged TCRα and TCRβ are subjected to thymic selection in the cortex and medulla, each stage ...
A guide to thymic selection of T cells - Nature
网页2023年7月18日 · MHC class-specific functions of CD4 + T helper cells, CD8 + killer T cells and CD4 + regulatory T cells are also established in the thymus. Finally, the thymus provides signals for the...
Adjusting to self in the thymus: CD4 versus CD8 lineage …
网页During that time, thymocytes undergoing positive selection experience changes in the expression of CD4 and CD8 co-receptors, as well as other molecules that modulate TCR responsiveness. TCR signaling dynamics are key to accurately link CD4 or CD8 expression, and the corresponding helper or killer effector functions, to MHC-II or MHC-I recognition.
The order and logic of CD4 versus CD8 lineage choice and
网页2021年1月4日 · In the unperturbed thymus, the order of coreceptor gene expression states is Cd4 + Cd8a + followed by Cd4 + Cd8a − and later by Cd4 − Cd8a +, providing direct support for sequential...
Adjusting to self in the thymus: CD4 versus CD8 lineage
网页2024年7月9日 · During thymic development, thymocytes adjust their TCR response based on the strength of their reactivity to self-peptide MHC complexes. This tuning process allows thymocytes with a range of self-reactivities to survive positive selection and contribute to a diverse T cell pool. In this review, we w ….
Development of double-positive thymocytes at single-cell …
网页2021年3月26日 · In the thymus, most CD4/CD8 double-negative (DN) precursors develop into the αβ-T cell lineage and then go through CD4/CD8 double-positive (DP) and CD4/CD8 single-positive (SP) stages to achieve maturation .
Thymus-Derived CD4+CD8+ Cells Reside in Mediastinal Adipose ... - PubMed
网页2021年12月1日 · Double-positive CD4 + CD8αβ + (DP) cells are thought to reside as T cell progenitors exclusively within the thymus. We recently discovered an unexpected CD4 + and CD8αβ + immune cell population in healthy and atherosclerotic mice by …