Anaphylaxis caused by tipepidine hibenzate, a central antitussive …
网页2014年12月2日 — Cough guidelines conclude that suppressant therapy is most effective when used for the short-term reduction of coughing and that relatively few drugs are effective as cough suppressants . In patients with cough due to upper respiratory infection, central cough suppressants have limited efficacy for symptomatic relief and are not recommended for ...
Tipepidine - Wikipedia
网页Tipepidine (brand names Asverin, Antupex, Asvelik, Asvex, Bitiodin, Cofdenin A, Hustel, Nodal, Sotal), also known as tipepidine hibenzate , is a synthetic, non-opioid antitussive and expectorant of the thiambutene class. [1] [2] It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs). [3]
Acute Confusional State Caused by Tipepidine Hibenzate …
网页Tipepidine hibenzate suppresses the cough reflex by acting on the cough center in the medulla, but the mechanism of its neurological side effects is unclear. It has been suggested that tipepidine inhibits the G protein-coupled inwardly …
Anaphylaxis caused by tipepidine hibenzate, a central antitussive drug ...
网页2014年12月2日 — In patients with cough due to upper respiratory infection, central cough suppressants have limited efficacy for symptomatic relief and are not recommended for this use. Tipepidine hibenzate, a central antitussive drug, has been used in Japan since 1959 and also in other Asian countries.
网页Tipepidine hibenzate is a non-opioid, centrally acting cough sup-pressant. Although overdose can cause altered mental status and other neurological symptoms, there have been no reports of tipepi-dine intoxication in an adult.
网页Tipepidine hibenzate, a central antitussive drug, is widely used in the manage-ment of cough and is generally safe and well tolerated. We present here a case of anaphylaxis...
Tipepidine in adolescent patients with depression: a 4 week, open …
网页2014年5月5日 — In conclusion, our pilot study suggests that tipepidine therapy may prove to be an effective alternative treatment for adolescent patients with depression. However, the long-term safety of tipepidine still needs to be assessed, as a cough suppressant therapy is usually completed within 1 week.
Tipepidine, a non-narcotic antitussive, exerts an antidepressant …
网页2016年4月1日 — We investigated whether tipepidine exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone (ACTH)-treated rats, which is known as a treatment-resistant depression model, and we studied the pharmacological mechanisms of the effects of tipepidine.
Tipepidine: Uses, Interactions, Mechanism of Action - DrugBank …
网页2017年6月23日 — R05DB24 — Tipepidine. R05DB — Other cough suppressants; R05D — COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS; R05 — COUGH AND COLD PREPARATIONS; R — RESPIRATORY SYSTEM; Drug Categories
Effects of tipepidine on MK-801-induced cognitive impairment …
网页2019年5月1日 — We previously reported that centrally acting non-narcotic antitussives, including tipepidine, inhibit G-protein-coupled inwardly rectifying potassium (GIRK) channel-activated currents of neurons. In addition, when administered at a cough suppressant dose, the drugs ameliorated the symptoms of variou …