耐药乙型肝炎 - 百度百科
网页耐药基因位点 (YMDD)位于聚合酶的C区 (rtM2041或rtM204V)，分别是YMDD中的蛋氨酸 (M)被 异亮氨酸 (I)或缬氨酸 (V)所替代，形成YIDD或YVDD变异，这两种变异分别是HBV基因组第739位碱基腺嘌呤被鸟嘌呤取代 (A→G)和第741位碱基鸟嘌呤被 胸腺嘧啶 取代 (G→T)。. 拉米夫定作用靶 ...
YMDD motif mutations in chronic hepatitis B antiviral treatment …
网页2012年5月1日 · This study aimed to determine the natural prevalence of variants of tyrosinemethionine- aspartic acid-aspartic acid (YMDD) motif in patients with chronic hepatitis B (CHB), and to explore its relation with demographic and clinical features, hepatitis B virus (HBV) genotypes, and HBV DNA levels.
YMDD variants of HBV DNA polymerase gene: Rapid detection …
网页2005年5月5日 · The patients were monitored intensively for liver enzymes, hepatitis B surface antigen (HBsAg) and HBV DNA in serum. Liver biopsy was performed regularly. HBV DNA in a conserved polymerase domain (the YMDD locus) was amplified from serum of each patient by PCR and sequenced.
Viral quasispecies of hepatitis B virus in patients with YMDD …
网页2019年2月11日 · The association between hepatitis B virus (HBV) quasispecies (QS) and the efficacy of nucleos (t)ide analog therapy is currently not well defined, particularly in the case of lamivudine (LAM)/adefovir (ADV) combination rescue therapy for patients with chronic HBV infection (CHB) presenting with LAM resistance.
Frontiers | Inflammation Pharmacological Reaction and YMDD …
网页2021年4月14日 · Background/Aims: Emergence of tyrosine-methionine-aspartate-aspartate (YMDD) motif in reverse transcriptase is a serious problem in chronic hepatitis B (CHB) patients after Lamivudine (LAM) therapy. However, the relationship between inflammation pharmacological reaction and YMDD mutational patterns of …
The Naturally Occurring YMDD Mutation among Patients …
网页2012年3月27日 · Several recent reports have demonstrated that tyrosine (Y)-methionine (M)-aspartic acid (D)-aspartic acid (D) (YMDD) motif mutations can naturally occur in chronic HBV patients without antiviral treatment such as lamivudine therapy.
The naturally occurring YMDD mutation among patients …
网页The YMDD-motif mutations can occur spontaneously with a relatively high incidence in CHB patients untreated with lamivudine. These mutations might be the consequence of accumulated base mismatch due to the nature of viral polymerase. More fundamental and clinical studies are needed to clarify the in ….
Detection of YMDD mutation using mutant-specific primers in …
网页2006年9月7日 · We used cloned YVDD, YIDD and wild-type HBV genomes as templates to determine the optimal conditions of mutant-specific PCR. A variety of primer construction (Table 1), primer concentration, dNTP concentration and annealing temperature of primers were systematically examined (data not shown).
YMDD motif mutations in chronic hepatitis B antiviral ... - PubMed
网页Objective: This study aimed to determine the natural prevalence of variants of tyrosine-methionine-aspartic acid-aspartic acid (YMDD) motif in patients with chronic hepatitis B (CHB), and to explore its relation with demographic and clinical features, hepatitis B virus (HBV) genotypes, and HBV DNA levels.
慢性HBV感染YMDD自然变异的研究进展
网页Abstract. Mutations of the hepatitis B virus (HBV) DNA polymerase, mainly occurring in the YMDD region, are related to resistance to lamivudine. Although these mutations often occur after lamivudine use, they can also emerge naturally. Many scholars have demonstrated the existence of natural YMDD mutations.