Zanamivir | C12H20N4O7 | CID 60855 - PubChem
网页Zanamivir, an antiviral agent, is a neuraminidase inhibitor indicated for treatment of uncomplicated acute illness due to influenza A and B virus in adults and pediatric patients 7 years and older who have been symptomatic for no more than 2 days.
Zanamivir - Wikipedia
网页Zanamivir is a medication used to treat and prevent influenza caused by influenza A and influenza B viruses. It is a neuraminidase inhibitor and was developed by the Australian biotech firm Biota Holdings. It was licensed to Glaxo in 1990 and approved in the US in 1999, only for use as a treatment for influenza.
Crystal structures of oseltamivir-resistant influenza virus ...
网页2008年5月14日 · Oseltamivir (Tamiflu) and zanamivir (Relenza) are two currently used neuraminidase inhibitors that were developed using knowledge of the enzyme structure 1, 2. It has been proposed that the...
The war against influenza: discovery and development of …
网页The discovery and development of zanamivir. The initial crystal structure 26,27 of influenza virus sialidase had a resolution of ∼ 3.0 Å, and consequently had limited value in structure-based...
The structure of H5N1 avian influenza neuraminidase suggests …
网页2006年8月16日 · Neuraminidases from influenza type A viruses form two genetically distinct groups: group-1 contains the N1 neuraminidase of the H5N1 avian virus and group-2 contains the N2 and N9 enzymes used for...
Structural Investigations and Binding Mechanisms of Oseltamivir …
网页2022年7月8日 · The virus is characteristically composed of three membrane proteins: neuraminidase, matrix protein (M2), and hemagglutinin. The presence of neuraminidase and hemagglutinin distinguishes types A and B and makes them …
Binding mechanism of oseltamivir and influenza neuraminidase …
网页2022年7月28日 · The binding-state zanamivir-NA (PDB ID: 6HCX) or peramivir-NA (PDB ID: 4MWV) in the crystal structure was used as the starting conformation and the system was constructed according to that of oseltamivir and NA (solvated in a water box with 15 Å water layer and 150 mmol/L of sodium chloride).
Zanamivir | C12H20N4O7 - ChemSpider
网页ChemSpider record containing structure, synonyms, properties, vendors and database links for Zanamivir, 139110-80-8, Relenza.
Design, synthesis and biological evaluation of novel zanamivir ...
网页2018年12月15日 · Zanamivir is one of the most potent NA inhibitors. In this paper, a series of zanamivir derivatives as potential NA inhibitors were studied by combination of molecular modeling techniques including 3D-QSAR, molecular docking, and …
Zanamivir: Uses, Interactions, Mechanism of Action - DrugBank …
网页2005年6月13日 · Zanamivir, an antiviral agent, is a neuraminidase inhibitor indicated for treatment of uncomplicated acute illness due to influenza A and B virus in adults and pediatric patients 7 years and older who have been symptomatic for no more than 2 days.