N-Acetylglutamic acid - Wikipedia
网页N -Acetylglutamic acid is an extracellular metabolite isolated from the prokaryote Rhizobium trifolii that was characterized using many structure determination techniques such as proton nuclear magnetic resonance (1 H NMR) spectroscopy, Fourier-transform infrared spectroscopy, and gas chromatography-mass spectrometry.
N-Acetylglutamate synthase - Wikipedia
网页N-Acetylglutamate synthase (NAGS) is an enzyme that catalyses the production of N-acetylglutamate (NAG) from glutamate and acetyl-CoA. Put simply NAGS catalyzes the following reaction: acetyl-CoA + L -glutamate → CoA + N -acetyl- L -glutamate
N-acetylglutamate synthase: structure, function and defects
网页N-acetylglutamate (NAG) is a unique enzyme cofactor, essential for liver ureagenesis in mammals while it is the first committed substrate for de novo arginine biosynthesis in microorganisms and plants.
N-乙酰谷氨酸合酶 - 维基百科，自由的百科全书
网页N-乙酰谷氨酸合酶（英語： N-acetylglutamate synthase ）是一个催化乙酰辅酶A与谷氨酸产生N-乙酰谷氨酸的酶。 对于细菌与植物来说，此酶十分重要，因为它是合成 精氨酸 途径中的一种酶。
The N-Acetylglutamate Synthase Family: Structures, Function and ...
网页2015年6月9日 · N-acetylglutamate synthase (NAGS) catalyzes the production of N-acetylglutamate (NAG) from acetyl-CoA and l-glutamate. In microorganisms and plants, the enzyme functions in the arginine biosynthetic pathway, while in mammals, its major role is to produce the essential co-factor of carbamoyl phosphate synthetase 1 (CPS1) in …
Gene delivery corrects N-acetylglutamate synthase deficiency …
网页2021年2月11日 · N-acetylglutamate synthase (NAGS; EC2.3.1.1) is a mitochondrial enzyme that catalyzes formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme A 3,4,5.
Presentation and management of N -acetylglutamate synthase …
网页2020年10月9日 · N-Acetylglutamate synthase (NAGS) deficiency is an extremely rare autosomal recessive metabolic disorder affecting the urea cycle, leading to episodes of hyperammonemia which can cause significant morbidity and mortality. Since its recognition in 1981, NAGS deficiency has been treated with carbamylglutamate with …
N-acetylglutamate synthase deficiency: an insight into the …
网页2011年8月24日 · N-acetylglutamate (NAG) is the required allosteric activator of carbamylphosphate synthetase (CPS1; EC 6.4.3.16), the first and rate limiting enzyme of urea cycle. 4, 5 NAG, in turn, is synthesized from glutamate and acetyl Co-enzyme A 6, 7 by the hepatic mitochondrial enzyme, N-acetylglutamate synthase (NAGS; EC 2.3.1.1).
N-乙酰谷氨酸合酶 - A+医学百科
网页N-乙酰谷氨酸合酶 （英语：N-acetylglutamate synthase）是一个 催化 乙酰辅酶A 与谷氨酸产生 N -乙酰谷氨酸 的酶。 对于 细菌 与植物来说，此酶十分重要，因为它是合成 精氨酸 途径中的一种酶。 此酶对哺乳动物来说亦十分重要，因为它可以产生 尿素循环 所需的调控物 N -乙酰谷氨酸，这种物质可以激活 氨甲酰磷酸合成酶Ⅰ，后者催化尿素循环的起始步骤。 目录. 1 临床意义. 2 参考文献. 3 外部链接. 4 参考来源. 临床意义. 编码此酶的 基因 若是 突变， …
N-Acetylglutamate Synthetase Deficiency - Medscape
网页2019年2月18日 · Normal enzyme function of N -acetylglutamate synthetase (NAGS) deficiency is confined to the hepatic mitochondria and mediates the reaction acetyl-coenzyme A (CoA) + glutamate → N...