Field cancerization - Wikipedia
网页Field cancerization or field effect (also termed field change, field change cancerization, field carcinogenesis, cancer field effect or premalignant field defect) is a biological process in which large areas of cells at a tissue surface or within …
Carcinisation - Wikipedia
网页Carcinisation (American English: carcinization) is a form of convergent evolution in which non-crab crustaceans evolve a crab -like body plan. The term was introduced into evolutionary biology by L. A. Borradaile, who described it as "the many attempts of Nature to evolve a crab". [2] Definition of carcinised morphology.
“田野癌化”/"区域癌化"现象 - 知乎 - 知乎专栏
网页2023年8月2日 · 其定义为一片粘膜区域内在先天遗传因素及后天生活环境,生活习惯等长期作用下,出现了大片的有缺陷的细胞,其对物理,化学及生物性的致癌因素敏感,渐次形成癌前病变乃至癌.已发现存在田野癌化的器官系统有:头颈部口腔,口咽,喉部的鳞状细胞癌;肺;Barrett食管与食管腺癌;阴道;子宫颈;结肠;乳腺;膀胱及皮肤.在食管鳞癌中尚未见到报道. 根据田野癌化的理论,癌即便被切除,在同一个解剖区域内仍然存在再发肿瘤的高危险性。 对一些病例而言, …
An evolutionary perspective on field cancerization - Nature
网页2017年12月8日 · Field cancerization, which is the replacement of the normal cell population by a cancer-primed cell population that may show no morphological change, is now recognized to underlie the...
Field Carcinogenesis in Cancer Evolution: What the Cell Is Going On?
网页2020年11月13日 · Molecular field carcinogenesis, also known as field cancerization, describes the inception of tumors from a preconditioned normal appearing or premalignant “field” of injured (e.g., carrying mutations) cells (1).
Field cancerization: Definition, epidemiology, risk factors, and ...
网页After completing this learning activity, participants should be able to define field cancerization and discuss how this condition differs from actinic keratoses; explain the pathogenesis of field cancerization; and describe the morbidity, mortality, and cost considerations associated with untreated or undertreated field cancerization.
Mechanisms that clear mutations drive field cancerization in …
网页2024年9月4日 · Here, to gain insight into the cellular mechanisms that inhibit the mutant clone expansion, and how they may be overcome by mutant cells to drive field cancerization, we map the fate of cells...
Field cancerization: Definition, epidemiology, risk factors, and ...
网页Field cancerization was first described in 1953 when pathologic atypia was identified in clinically normal tissue surrounding oropharyngeal carcinomas. The discovery of mutated fields surrounding primary tumors raised the question of whether the development of subsequent tumors within the field repr ….
Bridging tissue repair and epithelial carcinogenesis ... - Nature
网页2024年1月16日 · A Field cancerization, also named field change, represents the emergence of large tissue patches within an epithelium that look morphologically normal while being characterised by genetic or ...
Clinical implications and utility of field cancerization
网页2007年3月15日 · This review examines the concept of field cancerization in several cancers and its possible utility in four areas of oncology; risk assessment, early cancer detection, monitoring of tumor progression and definition of tumor margins.
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