Chlorozotocin - Pharmaceutical Drugs - NCBI Bookshelf
网页Chlorozotocin alkylates DNA and protein and causes DNA interstrand cross-links. In humans, it induces leukopenia and thrombocytopenia; in animals, it suppresses the bone marrow and affects immune response.
Chlorozotocin - Wikipedia
网页Chlorozotocin is a nitrosourea. It is used for cancer therapy. [citation needed] The International Agency for Research on Cancer concluded it was "probably carcinogenic" in 1990. It is an analogue of streptozotocin. References
氯脲霉素 - 百度百科
网页氯脲霉素，是一种有机化合物，化学式为C9H16ClN3O7。 [2] 2017年10月27日，世界卫生组织国际癌症研究机构公布的致癌物清单初步整理参考，氯脲霉素在2A类致癌物清单中。 [1] 中文名. 氯脲霉素. 外文名. Chlorozotocin. 化学式. C9H16ClN3O7. 分子量. 313.692. CAS登录号. 54749-90-5. 氯脲霉素，是一种有机化合物，化学式为C9H16ClN3O7。 2017年10月27日，世界卫生组织国际癌症研究机构公布的致癌物清单初步整理参考，氯脲霉素在2A类致 …
Chlorozotocin - an overview | ScienceDirect Topics
网页Chlorozotocin is a nitrosourea alkylating chemotherapeutic agent that is a water soluble chloroethyl derivative of streptozotocin. That is, for chlorozotocin a chloronitrosourea group at the 2 carbon position of glucose replaces …
Streptozocin–Doxorubicin, Streptozocin–Fluorouracil, or Chlorozotocin …
网页1992年2月20日 · Chlorozotocin was found to have therapeutic activity comparable to that of streptozocin plus fluorouracil, with considerably less emetic effect and more convenience in administration.
Chlorozotocin, an anti-tumour agent lacking bone marrow …
网页Chlorozotocin is a new nitrosourea anti-tumour drug that does not produce bone marrow suppression at therapeutic doses in mice. CDF1 mice which were injected i.p. with a dose lethal to 10% of animals within 60 days (LD10), 20 mg/kg, developed a 50% reduction in circulating peripheral blood lymphocytes without a decrease in circulating ...
Chlorozotocin | C9H16ClN3O7 | CID 301389 - PubChem
网页Chlorozotocin is a glucose-linked chloroethylnitrosourea with potential antineoplastic activity. Chlorozotocin alkylates DNA and proteins, induces the formation of interstrand DNA and DNA-protein crosslinks, and causes DNA strand breakage, thereby damaging DNA and resulting in cell death.
Chlorozotocin - PMC - National Center for Biotechnology …
网页Chlorozotocin is a chloroethyl nitrosourea with a glucose carrier that has curative activity for the murine L1210 leukemia, but is nonmyelosuppressive in mice. To determine the mechanism for this unique property of reduced bone marrow toxicity, comparative studies were conducted with chlorozotocin and CCNU, a myelotoxic chloroethyl nitrosourea.
Preclinical and Clinical Studies on Chlorozotocin, a New
网页Chlorozotocin is a glucose-substituted chloroethyl nitrosourea with pharmacologic properties suggesting it is a relatively nonmyelosuppressive cancer chemotherapy drug. Preclinical studies have shown that this drug possesses approximately twice the in vitro alkylating activity of the chloroethyl nitrosoureas BCNU and CCNU.
Chlorozotocin: MECHANISM OF REDUCED BONE MARROW …
网页Chlorozotocin is a chloroethyl nitrosourea with a glucose carrier that has curative activity for the murine L1210 leukemia, but is nonmyelosuppressive in mice. To determine the mechanism for this unique property of reduced bone marrow toxicity, comparative studies were conducted with chlorozotocin and CCNU, a myelotoxic chloroethyl nitrosourea.