NCI Division of Cancer Treatment and Diagnosis (DCTD)
网页DCTD is a division of NCI that develops novel diagnostics and therapies for cancer. It funds and conducts research, clinical trials, and data analysis in various areas, such as biomarkers, imaging, radiation, and complementary medicine.
Gene Expression and Methylation Analyses Suggest DCTD as a …
网页2017年9月14日 · The gene coding a key enzyme in genetic material synthesis, dCMP deaminase (DCTD), was found to be significantly correlated with overall survival and high level of DCTD mRNA indicated shorter...
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Intratumoural expression of deoxycytidylate deaminase or …
网页2018年3月9日 · Deoxycytidylate deaminase (DCTD) and ribonucleotide reductase subunit M1 (RRM1) are potential prognostic and predictive biomarkers for pyrimidine-based chemotherapy in pancreatic adenocarcinoma.
Administration of deoxyribonucleosides or inhibition of their ...
网页2013年12月20日 · In a previous study, we found that dThd-induced mtDNA depletion can be prevented or reverted by deoxycytidine (dCtd) in cell culture and proposed that treatment with this nucleoside could prevent mtDNA depletion in MNGIE . However, rapid dCtd deamination by the ubiquitous enzyme cytidine deaminase (CDA) would limit dCtd availability in vivo ...
C4-dicarboxylate carriers and sensors in bacteria - ScienceDirect
网页2002年1月17日 · Phosphorylated DctD binds cooperatively to a tandem upstream activator site by a C-terminal helix-turn-helix DNA binding motif. DctD interacts with σ 54 and the β subunit of RNA polymerase, like NtrC and other σ 54 -dependent transcriptional regulators.
Negative regulation of sigma 54-dependent dctA expression by …
网页In the presence of C4-dicarboxylates, the DCTB sensor protein is believed to phosphorylate and activate DCTD, which in turn activates transcription at the sigma 54-dependent dctA promoter. Here, we present evidence that in addition to activating dctA transcription, DCTD can also repress expression of dctA.
Purification and Characterization of the AAA+ Domain of
网页The DctD AAA+ domain was significantly more soluble than DctD (Δ 1-142), a truncated DctD protein consisting of the AAA+ and DNA-binding domains. In addition, the DctD AAA+ domain was more homogeneous than DctD ( Δ 1-142) when analyzed by native gel electrophoresis, migrating predominantly as a single …
Mutational Analysis of the Phosphate-Binding Loop of
网页DctD activates transcription from dctA, which encodes a permease for C 4-dicarboxylic acids. It forms a two-component regulatory system with DctB that positively regulates expression from dctA (2, 7, 8, 18). In this study, we used DctD (Δ1-142), which is a truncated, constitutively active form of DctD that lacks the N-terminal regulatory domain .
NtrBC-dependent expression from the Rhizobium meliloti dctA …
网页1995年5月15日 · Effects of the two-component sensor-regulator pairs DctBD and NtrBC upon the expression of a dctA::phoA fusion from Rhizobium meliloti were determined under excess and limiting nitrogen concentrations in Escherichia coli. Results indicated that NtrBC affected transcription from the dctA promoter on a number of regulatory levels and under ...
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