MAPK/ERK pathway - Wikipedia
网页The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell. The signal starts when a signaling molecule binds to the receptor on the cell surface and ends when the DNA in the nucleus expresses a ...
ERK signalling: a master regulator of cell behaviour, life and fate
网页2020年6月23日 · The early growth response (EGR), FOS, JUN and MYC families of transcription factors are the main IEG products involved in cell proliferation that are robustly induced by ERK-regulated SRF–TCF ...
Epidermal Growth Factor Receptor Cell Proliferation Signaling …
网页2017年5月17日 · EGFR-induced activation of the ERK and PI3K-AKT pathways plays a crucial role in the induction of CYCLIN D, which cascades into E2F-mediated progression past G1 and the R point. More specifically, CDK4/6- CYCLIN D phosphorylates RB at Ser807 and Ser811, causing the release of E2F, and free E2F helps transcribe key genes for the transition of G1 ...
Epidermal Growth Factor (EGF) Receptor-dependent ERK …
网页In COS-7 cells, α 2A-adrenergic receptors (ARs) stimulate ERK phosphorylation via two distinct pathways, a transactivation pathway that involves the release of HB-EGF and the EGFR and an alternate pathway that is independent of both HB-EGF and the EGFR. We have developed a mixed culture system to study the mechanism of …
干货：九大肿瘤相关信号通路介绍-EGFR通路及靶标介绍（一）
网页肿瘤表皮生长因子受体(EGFR)是一个170KDa的跨膜糖蛋白受体酪氨酸激酶，由表皮生长因子激活，影响细胞的生长和分化。 EGFR 家族又称为EGFR酪氨酸激酶家族，由4个不同的受体酪氨酸激酶(PTK)组成，分别为EGFR(HER-1/ErbB-1)、ErbB-2(HER-2/neu)、ErbB-3(HER-3)和ErbB-4(HER-4)。
Synergistic anticancer effect by targeting CDK2 and EGFR-ERK
网页2024年1月1日 · The EGFR-RAS-ERK pathway is one of the most important signaling cascades in cell survival, growth, and proliferation. Aberrant activation of this pathway is a common mechanism in various cancers. Here, we report that CDK2 is a novel regulator of the ERK pathway via USP37 deubiquitinase (DUB).
Quantifying single-cell ERK dynamics in colorectal cancer …
网页2021年4月1日 · Direct targeting of the downstream mitogen-activated protein kinase (MAPK) pathway to suppress extracellular-regulated kinase (ERK) activation in KRAS and BRAF mutant colorectal cancer (CRC) has...
STAT3 attenuates EGFR-mediated ERK activation and cell ... - PubMed
网页ERK is activated via the canonical epidermal growth factor receptor (EGFR)-Ras-MEK pathway, which could be attenuated by oxidants. We now show that the failure to activate ERK in a sustained manner during severe oxidative stress is owing to the activation of the signal transducer and activator of transcription-3 …
Differential roles of ERK and Akt pathways in regulation of EGFR ...
网页2010年6月21日 · Our novel findings suggest that EGF-triggered ERK activation has profound feedback on EGFR signaling and trafficking by EGFR threonine phosphorylation, whereas Akt has a pivotal role in...
生物医药靶点赛道：ERK 1/2 通路-EGFR（1） - 雪球
网页2022年8月17日 · 当 rtk 区域发生激活突变时，变异的 egfr 无需与配体结合即可拥有持续的酪氨酸酶活性，导致 egfr 的持续活化，持续的激活下游信号通路（erk），持续地磷酸化 elk1, ets, fos, jun, myc 和 sp1 等转录因子，诱导与细胞周期与细胞增殖有关的基因表达，诱导肿瘤 …
- 某些结果已被删除
跳至内容