Glycosylation - Wikipedia
网页Glycosylation is the reaction in which a carbohydrate (or 'glycan'), i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another molecule (a glycosyl acceptor) in order to form a glycoconjugate.
Glycosylation: mechanisms, biological functions and clinical ...
网页2024年8月5日 · Glycosylation is crucial in regulating protein stability. Glycosylation can enhance the stability and solubility of proteins, thereby improving their half-life and drug properties in vivo.
Glycosylation in health and disease - Nature Reviews Nephrology
网页2019年3月11日 · Glycosylation refers to the addition of carbohydrate chains to proteins and lipids. In this Review, the authors discuss the broad role of glycans in immunity, cancer, xenotransplantation and ...
网页glycosylation, also known as O-glycosylation mucins, is expressed in a variety of tumor types and plays a role in cell-cell interaction, and cell-matrix interactions. 25 On the other hand, the ...
Glycosylation - an overview | ScienceDirect Topics
网页Glycosylation is the essential posttranslational modification that occurs in various cellular compartments, leading to a range of genetic disorders known as congenital disorders of glycosylation (CDG), which often involve severe multisystem manifestations, particularly affecting the nervous system.
Glycosylation - an overview | ScienceDirect Topics
网页Glycosylation is a complex form of protein modification occurring in the secretory pathway. The addition of N - and O -glycans affects intracellular processes like the folding and trafficking of most glycoproteins.
Protein glycosylation: Current Biology - Cell Press
网页2019年4月1日 · What is protein glycosylation? Protein glycosylation is the covalent attachment of single sugars or glycans, i.e., multi-sugar polysaccharides or complex oligosaccharides, to select residues of target proteins.
An Overview of Glycosylation and its Impact on Cardiovascular …
网页2021年11月16日 · Glycosylation is a co- and post-translational process where carbohydrates are covalently attached to carbohydrates, polypeptides, lipids, polynucleotides, usually catalyzed by glycosyltransferase enzymes, using specific substrates of sugar-nucleotide donors (Seeberger, 2017).
Understanding glycosylation: Regulation through the metabolic …
网页2023年10月1日 · Glycosylation is a highly dynamic, multi-layered post-translational modification. • Metabolic flux through precursor pathways is vital for sustained glycan synthesis. • Inflammation induces profound glycosylation changes. • Metabolic inhibition of glycan synthesis results in altered glycosylation signature.
Glycosylation in health and disease - PMC - National Center for ...
网页We review how glycosylation patterns are altered in multiple hum an diseases, including congenital disorders of glycosylation (C D G s) as well as auto-immune, infectious and chronic inflammatory diseases, and cancer.
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