mTOR - Wikipedia
网页The mammalian target of rapamycin (mTOR), [5] also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. [6] [7] [8] mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein ...
mTOR 通路 | Cell Signaling Technology
网页哺乳动物雷帕霉素靶蛋白 (mTOR) 是一种非典型的丝氨酸/苏氨酸激酶，存在于两个不同的复合体中。 第一个为 mTOR 复合体 1 (mTORC1)，由 mTOR、Raptor、GβL 和 DEPTOR 构成，受 rapamycin 抑制。
mTOR Signaling in Growth, Metabolism, and Disease
网页2017年3月3日 · mTOR is a serine/threonine protein kinase in the PI3K-related kinase (PIKK) family that forms the catalytic subunit of two distinct protein complexes, known as mTOR Complex 1 (mTORC1) and 2 (mTORC2) (Fig. 1A). mTORC1 is defined by its three core components: mTOR, Raptor (regulatory protein associated with mTOR), and mLST8 (mammalian lethal with ...
Multifaceted role of mTOR (mammalian target of rapamycin) …
网页2023年10月2日 · The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to maintain ...
mTOR-what does it do? - PubMed
网页Target of rapamycin (TOR) is a highly conserved serine/threonine kinase that controls cell growth and metabolism in response to nutrients, growth factors, cellular energy, and stress. TOR, which was originally discovered in yeast, is conserved in all eukaryotes including plants, worms, flies, and ma ….
综述浅读| mTOR到底是个啥 - 知乎 - 知乎专栏
网页哺乳动物雷帕霉素靶蛋白 (mammalian target of rapamycin, mTOR)是一种非典型丝氨酸/苏氨酸蛋白激酶，为磷脂酰肌醇激酶相关激酶 (phosphatidy-linositol kinase-related kinase, PIKK)蛋白质家族成员。. mTOR 进化上相对保守，可整合 营养 、 能量 及 生长因子 等多种细胞外信号，参与 ...
mTOR信号通路：细胞的调节器，药物的靶点，科学的前沿 - 知乎
网页2023年9月26日 · mTOR是 哺乳动物雷帕霉素靶蛋白 （mammalian target of rapamycin）的缩写，它是一种丝氨酸/苏氨酸蛋白激酶，属于PI3K/Akt信号通路的下游效应子。 mTOR可以与不同的蛋白质形成两种复合体，即mTORC1和mTORC2，它们在细胞内有不同的定位和功能。 mTORC1是mTOR复合体1的缩写，它由mTOR、Raptor、PRAS40、DEPTOR和MLST8等蛋白质组成。 mTORC1主要响应营养、能量和生长因子等信号，通过磷酸化下 …
mTOR pathway: A current, up-to-date mini-review (Review)
网页2014年10月10日 · Mammalian target of rapamycin (mTOR) is a component of the phosphatidylinositol 3-kinase (PI3K) cell survival pathway that monitors the availability of nutrients, mitogenic signals and cellular energy and oxygen levels, and therefore is significant in the regulation of cell growth and proliferation .
mTOR kinase structure, mechanism and regulation | Nature
网页2013年5月1日 · The mTOR (mammalian target of rapamycin) pathway is a central regulator of cell growth in response to environmental signals such as energy, nutrients and growth factors, and is misregulated in...
mTOR: from growth signal integration to cancer, diabetes and …
网页2010年12月15日 · The mammalian target of rapamycin (mTOR) is a highly conserved kinase that belongs to the phosphoinositide 3-kinase-related protein kinases (PIKK) family. mTOR participates in...